Document Detail

Mathematical models for combined high pressure and thermal plasmin inactivation kinetics in two model systems.
MedLine Citation:
PMID:  15545364     Owner:  NLM     Status:  MEDLINE    
The combined high-pressure thermal inactivation kinetics of plasmin was studied in 2 model systems. The first system contained both plasmin and plasminogen, whereas, in the second system, all plasminogen was converted into plasmin, with urokinase, before the inactivation studies. High-pressure treatments were conducted in the range of 300 to 800 MPa combined with temperatures from 30 to 65 degrees C. Under all conditions of pressure and temperature (isobaric-isothermal) studied, for both systems, first-order inactivation was observed. A third-degree polynomial model (derived from thermodynamic principles) successfully described the temperature and pressure dependence of the inactivation rate constant over the entire experimental domain. The antagonistic effect and the stabilization effect observed above a threshold pressure value of 600 MPa were thought to be related to the disruption of disulfide bonds in plasmin and plasminogen.
D Borda; A Van Loey; C Smout; M Hendrickx
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  87     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-16     Completed Date:  2005-04-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4042-9     Citation Subset:  IM    
Department of Food Bioengineering, Faculty of Food Science and Engineering, University Dunarea de Jos, 111 Domneasca Street, 800201 Galati, Romania.
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MeSH Terms
Dairy Products / standards
Fibrinolysin / chemistry*
Food Technology / methods*
Hot Temperature
Milk / enzymology*
Models, Theoretical*
Plasminogen / metabolism
Reg. No./Substance:
9001-91-6/Plasminogen; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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