Document Detail


Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes.
MedLine Citation:
PMID:  16735539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immature oocytes benefit from nutrient modification of the follicular environment by the surrounding cumulus mass. However, the oxygen concentration that the oocyte may be exposed to could be lower than the antral follicular concentration due to the metabolism of surrounding cumulus cells. Using metabolic data previously determined, we have developed a mathematical model of O(2) diffusion across the bovine and murine cumulus-oocyte complex. From this we have determined that across a physiological range of external pO(2), less than 0.25% and 0.5% O(2) is removed by cumulus cells within the bovine and murine cumulus-oocyte complex respectively. Our model differs from others as it: incorporates a term that allows for nonlinear variation of the oxygen consumption rate with oxygen concentration; considers two regions (oocyte and cumulus) sharing a common boundary, both of which consume oxygen at different non linear rates. Cumulus cells therefore remove little O(2), thus sparing this essential gas for the oocyte, which is dependent on ATP generation via oxidative phosphorylation.
Authors:
A R Clark; Y M Stokes; M Lane; J G Thompson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  131     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-31     Completed Date:  2006-10-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  999-1006     Citation Subset:  IM    
Affiliation:
School of Mathematical Sciences and Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, The University of Adelaide, SA, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Diffusion
Female
Mice
Models, Biological
Models, Statistical
Oocytes / metabolism*
Oogenesis / physiology*
Ovarian Follicle / metabolism*
Oxygen / metabolism*
Grant Support
ID/Acronym/Agency:
U01 HD044644/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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