| Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes. | |
| | |
MedLine Citation:
|
PMID: 16735539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Immature oocytes benefit from nutrient modification of the follicular environment by the surrounding cumulus mass. However, the oxygen concentration that the oocyte may be exposed to could be lower than the antral follicular concentration due to the metabolism of surrounding cumulus cells. Using metabolic data previously determined, we have developed a mathematical model of O(2) diffusion across the bovine and murine cumulus-oocyte complex. From this we have determined that across a physiological range of external pO(2), less than 0.25% and 0.5% O(2) is removed by cumulus cells within the bovine and murine cumulus-oocyte complex respectively. Our model differs from others as it: incorporates a term that allows for nonlinear variation of the oxygen consumption rate with oxygen concentration; considers two regions (oocyte and cumulus) sharing a common boundary, both of which consume oxygen at different non linear rates. Cumulus cells therefore remove little O(2), thus sparing this essential gas for the oocyte, which is dependent on ATP generation via oxidative phosphorylation. |
| | |
Authors:
|
A R Clark; Y M Stokes; M Lane; J G Thompson |
Related Documents
:
|
11209539 - Effects of controlled ovarian hyperstimulation on oocyte quality in terms of the incide... 9603249 - Differentiation of the corpus luteum of the mink (mustela vison): mitogenic and steroid... 20045459 - Human steroidogenic factor-1 (hsf-1) regulates progesterone biosynthesis and growth of ... 18037889 - Follicular shuttling of marginal zone b cells facilitates antigen transport. 17636169 - Implication of cortisol and 11beta-hydroxysteroid dehydrogenase enzymes in the developm... 15474089 - Activation of soluble guanylyl cyclase inhibits estradiol production and cyclic amp acc... 2543879 - Beta 1-adrenoceptors in rat hepatoma. desensitization by isoproterenol and phorbol-myri... 20503369 - Cellular dynamics of epithelial clefting during branching morphogenesis of the mouse su... 2184039 - Distribution of peroxisomes and glycolate metabolism in relation to calcium oxalate for... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Reproduction (Cambridge, England) Volume: 131 ISSN: 1470-1626 ISO Abbreviation: Reproduction Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-31 Completed Date: 2006-10-04 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
|
Languages: eng Pagination: 999-1006 Citation Subset: IM |
Affiliation:
|
School of Mathematical Sciences and Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, The University of Adelaide, SA, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cattle Diffusion Female Mice Models, Biological Models, Statistical Oocytes / metabolism* Oogenesis / physiology* Ovarian Follicle / metabolism* Oxygen / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
U01 HD044644/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction of labour at the start of the new millennium.
Next Document: Platelet-derived growth factor modulates the primordial to primary follicle transition.