Document Detail


Mathematical modelling of immunotherapy in HIV infection.
MedLine Citation:
PMID:  7851617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of active or passive immunotherapy on HIV infection was simulated using a mathematical model of CD4+ lymphocyte depletion. Permanently effective active immunotherapy increased CD4+ lymphocyte counts to a steady-state level depending on the intensity of the therapy. Active HIV immunization effective for one or more years increased CD4+ lymphocyte counts during the treatment period and prolonged survival substantially; this prolongation exceeded the time interval of therapy duration. Intensive passive immunotherapy by anti-HIV antibodies led to a temporary increase of CD4+ lymphocyte numbers and an apparent prolongation of survival.
Authors:
J Dolezal; T Hraba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia biologica     Volume:  40     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-10     Completed Date:  1995-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM; X    
Affiliation:
Institute of Information Theory and Automation, Academy of Sciences of the Czech Republic, Praha.
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MeSH Terms
Descriptor/Qualifier:
CD4 Lymphocyte Count
HIV Infections / immunology,  therapy*
Humans
Immunotherapy*
Immunotherapy, Adoptive
Models, Immunological*

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