Document Detail


Mathematical modeling of planar cell polarity to understand domineering nonautonomy.
MedLine Citation:
PMID:  15662015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy.
Authors:
Keith Amonlirdviman; Narmada A Khare; David R P Tree; Wei-Shen Chen; Jeffrey D Axelrod; Claire J Tomlin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  307     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-21     Completed Date:  2005-02-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-6     Citation Subset:  IM    
Affiliation:
Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305-4035, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing
Alleles
Animals
Cell Membrane / metabolism
Cell Polarity*
Diffusion
Drosophila / cytology*,  genetics,  metabolism
Drosophila Proteins / genetics,  metabolism
Feedback, Physiological
Frizzled Receptors
Mathematics
Membrane Proteins / genetics,  metabolism
Models, Biological*
Mutation
Phenotype
Phosphoproteins / genetics,  metabolism
Protein Binding
Receptors, G-Protein-Coupled
Signal Transduction*
Wing / cytology*,  metabolism
Grant Support
ID/Acronym/Agency:
R01-GM59823/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Drosophila Proteins; 0/Frizzled Receptors; 0/Membrane Proteins; 0/Phosphoproteins; 0/Receptors, G-Protein-Coupled; 0/Vang protein, Drosophila; 0/dishevelled proteins; 0/fz protein, Drosophila
Comments/Corrections
Comment In:
Dev Cell. 2005 Feb;8(2):134-6   [PMID:  15691754 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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