Document Detail

Mathematical modeling of planar cell polarity to understand domineering nonautonomy.
MedLine Citation:
PMID:  15662015     Owner:  NLM     Status:  MEDLINE    
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy.
Keith Amonlirdviman; Narmada A Khare; David R P Tree; Wei-Shen Chen; Jeffrey D Axelrod; Claire J Tomlin
Related Documents :
3795985 - Simulation analysis of excitation conduction in the heart: propagation of excitation in...
11937285 - A model based upon pseudo regular spacing of cells combined with the randomisation of t...
22872475 - Stem cell proliferation versus meiotic fate decision in caenorhabditis elegans.
19622435 - A stochastic broadcast feedback approach to regulating cell population morphology for m...
18050485 - Intracellular trafficking.
9804055 - Cardiac cell volume: crystal clear or murky waters? a comparison with other cell types.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  307     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-21     Completed Date:  2005-02-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-6     Citation Subset:  IM    
Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305-4035, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptor Proteins, Signal Transducing
Cell Membrane / metabolism
Cell Polarity*
Drosophila / cytology*,  genetics,  metabolism
Drosophila Proteins / genetics,  metabolism
Feedback, Physiological
Frizzled Receptors
Membrane Proteins / genetics,  metabolism
Models, Biological*
Phosphoproteins / genetics,  metabolism
Protein Binding
Receptors, G-Protein-Coupled
Signal Transduction*
Wing / cytology*,  metabolism
Grant Support
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Drosophila Proteins; 0/Frizzled Receptors; 0/Membrane Proteins; 0/Phosphoproteins; 0/Receptors, G-Protein-Coupled; 0/Vang protein, Drosophila; 0/dishevelled proteins; 0/fz protein, Drosophila
Comment In:
Dev Cell. 2005 Feb;8(2):134-6   [PMID:  15691754 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mechanism of hsp70i gene bookmarking.
Next Document:  T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.