| Mathematical modeling of planar cell polarity to understand domineering nonautonomy. | |
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MedLine Citation:
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PMID: 15662015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy. |
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Authors:
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Keith Amonlirdviman; Narmada A Khare; David R P Tree; Wei-Shen Chen; Jeffrey D Axelrod; Claire J Tomlin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 307 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-21 Completed Date: 2005-02-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 423-6 Citation Subset: IM |
Affiliation:
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Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305-4035, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing Alleles Animals Cell Membrane / metabolism Cell Polarity* Diffusion Drosophila / cytology*, genetics, metabolism Drosophila Proteins / genetics, metabolism Feedback, Physiological Frizzled Receptors Mathematics Membrane Proteins / genetics, metabolism Models, Biological* Mutation Phenotype Phosphoproteins / genetics, metabolism Protein Binding Receptors, G-Protein-Coupled Signal Transduction* Wing / cytology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01-GM59823/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Drosophila Proteins; 0/Frizzled Receptors; 0/Membrane Proteins; 0/Phosphoproteins; 0/Receptors, G-Protein-Coupled; 0/Vang protein, Drosophila; 0/dishevelled proteins; 0/fz protein, Drosophila |
| Comments/Corrections | |
Comment In:
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Dev Cell. 2005 Feb;8(2):134-6
[PMID:
15691754
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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