| Mathematical modeling of the malignancy of cancer using graph evolution. | |
| | |
MedLine Citation:
|
PMID: 17462676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report a novel computational method based on graph evolution process to model the malignancy of brain cancer called glioma. In this work, we analyze the phases that a graph passes through during its evolution and demonstrate strong relation between the malignancy of cancer and the phase of its graph. From the photomicrographs of tissues, which are diagnosed as normal, low-grade cancerous and high-grade cancerous, we construct cell-graphs based on the locations of cells; we probabilistically generate an edge between every pair of cells depending on the Euclidean distance between them. For a cell-graph, we extract connectivity information including the properties of its connected components in order to analyze the phase of the cell-graph. Working with brain tissue samples surgically removed from 12 patients, we demonstrate that cell-graphs generated for different tissue types evolve differently and that they exhibit different phase properties, which distinguish a tissue type from another. |
| | |
Authors:
|
Cigdem Gunduz-Demir |
Related Documents
:
|
3306366 - Plant cells at different stages in their growth curve differentially activate promutagens. 22190706 - Production of chicken progeny (gallus gallus domesticus) from interspecies germline chi... 20969896 - Susceptibility of hep3b cells in different phases of cell cycle to tbid. 12415566 - Incorporation of [1-14c]-linoleic acid by llc-wrc256 tumour cells. 3409226 - Expression of fibronectin on clonally related transformed and control sublines from an ... 8671336 - Fertilization promoting peptide, a tripeptide similar to thyrotrophin-releasing hormone... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-27 |
Journal Detail:
|
Title: Mathematical biosciences Volume: 209 ISSN: 0025-5564 ISO Abbreviation: Math Biosci Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-09-18 Completed Date: 2007-12-06 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0103146 Medline TA: Math Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 514-27 Citation Subset: IM |
Affiliation:
|
Department of Computer Engineering, Bilkent University, Ankara TR-06800, Turkey. gunduz@cs.bilkent.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Brain Neoplasms / pathology* Glioma / pathology Humans Image Processing, Computer-Assisted / methods*, statistics & numerical data Mathematics Models, Biological* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On Haldane's formulation of Luria and Delbrück's mutation model.
Next Document: Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1.