Document Detail

Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?
MedLine Citation:
PMID:  8063263     Owner:  NLM     Status:  MEDLINE    
This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.
R Bellazzi; C Siviero; R Bellazzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Haematologica     Volume:  79     ISSN:  0390-6078     ISO Abbreviation:  Haematologica     Publication Date:    1994 Mar-Apr
Date Detail:
Created Date:  1994-09-20     Completed Date:  1994-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  154-64     Citation Subset:  IM    
Dipartimento di Informatica e Sistemistica, Università di Pavia, Italy.
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MeSH Terms
Anemia / drug therapy*,  etiology
Cost-Benefit Analysis
Erythropoietin / therapeutic use*
Models, Statistical*
Uremia / complications
Reg. No./Substance:

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