Document Detail


Mathematical model for satellite associations of human acrocentric chromosomes.
MedLine Citation:
PMID:  19075353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Short arms, satellite stalks and satellites of human acrocentric chromosomes (13, 14, 15, 21 and 22) represent heterochromatic regions. Enforced by mutual attraction of heterochromatic regions, the short arms of acrocentric chromosomes come close to each other and compose associations. The associations of human acrocentric chromosomes cause nucleolus formation, undergo age-related changes, account for elevated incidence of chromosome rearrangements and, consequently, can cause chromosome diseases. Most acrocentric chromosome associations are formed by chromatid satellite stalks. This work contains results of acrocentric association rates assessed with use of newly designed mathematical model, which is based on two parameters: the probability of formation and the association intensity for different acrocentric chromosome pairs. For middle-aged individuals the following values were defined: S(0) = 0.558, lambda(V) = 0.2706, lambda(V) = 0.4768 and lambda(W) = 0.0960. The new mathematical model for satellite associations makes it possible to compare two cells not only by the total number of acrocentric chromosome associations, but also by the type and character of each association.
Authors:
T Lezhava; Z Tsigroshvili; N Dvalishvili; T Jokhadze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Georgian medical news     Volume:  -     ISSN:  1512-0112     ISO Abbreviation:  Georgian Med News     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101218222     Medline TA:  Georgian Med News     Country:  Georgia (Republic)    
Other Details:
Languages:  eng     Pagination:  90-9     Citation Subset:  IM    
Affiliation:
Iv. Javakhishvili Tbilisi State University.
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MeSH Terms
Descriptor/Qualifier:
Centromere / genetics*
Chromosomes, Human / genetics*
DNA, Satellite / genetics*
Humans
Models, Genetic*
Chemical
Reg. No./Substance:
0/DNA, Satellite

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