Document Detail


Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge.
MedLine Citation:
PMID:  16899679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We constructed a mathematical model of the early response to Escherichia coli infection of the mammary gland and explored the roles and interactions between inflammatory cells and bacteria. The model incorporates 3 equations that describe the interactions among bacteria, milk somatic cells, and blood leukocyte densities. These 3 equations were fitted to cell densities observed during acute inflammatory responses in unvaccinated and vaccinated heifers inoculated with 10(4) or 10(6) cfu of E. coli. The rates computed for the cellular transit from the storage sites to the blood and from the blood to the milk were lower in cows receiving 10(4) cfu but increased at approximately 6 x 10(-6) and 30 x 10(-6) microL/cfu per h in nonvaccinated or vaccinated cows inoculated with 10(6) cfu, respectively. The cellular rates of bacterial killing were highest in unvaccinated cows ( approximately 400 x 10(-6) microL/cell per h) when compared with vaccinated cows (200 to 300 x 10(-6) microL/cell per h). A critical density of milk somatic cells at which bacteria density is constant was computed from the model at 2 x 10(6) cells/mL, and a one-way sensitivity analysis revealed that the changes in milk cellular densities were mostly sensitive to variations in the rate of bacterial killing and in the rate of production of inflammatory cells.
Authors:
J Detilleux; F Vangroenweghe; C Burvenich
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  89     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2008-04-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3455-65     Citation Subset:  IM    
Affiliation:
Faculty of Veterinary Medicine, University of Liège, Department of Quantitative Genetics, Liege 4000, Belgium. jdetilleux@ulg.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Area Under Curve
Bacterial Vaccines / administration & dosage,  immunology
Cattle
Cell Count / veterinary
Colony Count, Microbial / veterinary
Escherichia coli / immunology*
Escherichia coli Infections / immunology*
Female
Mammary Glands, Animal / immunology*,  microbiology,  pathology
Mastitis, Bovine / immunology*,  microbiology
Models, Biological*
Chemical
Reg. No./Substance:
0/Bacterial Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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