Document Detail


Mathematical Modeling of Respiratory System Mechanics in the Newborn Lamb.
MedLine Citation:
PMID:  23381500     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this paper, a mathematical model of the respiratory mechanics is used to reproduce experimental signal waveforms acquired from three newborn lambs. As the main challenge is to determine specific lamb parameters, a sensitivity analysis has been realized to find the most influent parameters, which are identified using an evolutionary algorithm. Results show a close match between experimental and simulated pressure and flow waveforms obtained during spontaneous ventilation and pleural pressure variations acquired during the application of positive pressure, since root mean square errors equal to 0.0119, 0.0052 and 0.0094. The identified parameters were discussed in light of previous knowledge of respiratory mechanics in the newborn.
Authors:
Virginie Le Rolle; Nathalie Samson; Jean-Paul Praud; Alfredo I Hernández
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-5
Journal Detail:
Title:  Acta biotheoretica     Volume:  -     ISSN:  1572-8358     ISO Abbreviation:  Acta Biotheor.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421520     Medline TA:  Acta Biotheor     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
INSERM, U1099, Rennes, 35000, France, virginie.lerolle@univ-rennes.fr.
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