| Mathematical modeling of flow-generated forces in an in vitro system of cardiac valve development. | |
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MedLine Citation:
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PMID: 19862617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart valve defects are the most common cardiac defects. Therefore, defining the mechanisms of cardiac valve development is critical to our understanding and treatment of these disorders. At early stages of embryonic cardiac development, the heart begins as a simple tube that then becomes constricted into separate atrial and ventricular regions by the formation of small, mound-like structures, called atrioventricular (AV) cushions. As valve development continues, these mounds fuse and then elongate into valve leaflets. A longstanding hypothesis proposes that blood flow-generated shear stress and pressure are critical in shaping the cushions into leaflets. Here we show results from a two-dimensional mathematical model that simulates the forces created by blood flow present in a developing chick heart and in our in vitro, tubular model system. The model was then used to predict flow patterns and the resulting forces in the in vitro system. The model indicated that forces associated with shear stress and pressure have comparable orders of magnitude and collectively produce a rotational profile around the cushion in the direction of flow and leaflet growth. Further, it was concluded that the replication of these forces on a cushion implanted in our tubular in vitro system is possible. Overall, the two-dimensional, mathematical model provides insight into the forces that occur during early cardiac valve elongation. |
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Authors:
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Stefanie V Biechler; Jay D Potts; Michael J Yost; Lorain Junor; Richard L Goodwin; John W Weidner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-28 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 38 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-03-23 Revised Date: 2011-06-02 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 109-17 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, University of South Carolina, 3C05, 301 Main St., Columbia, SC 29208, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chick Embryo Heart Valve Diseases / pathology, physiopathology* Heart Valves / embryology*, pathology, physiopathology* Humans Models, Cardiovascular* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL086856-03/HL/NHLBI NIH HHS; R01HL086856/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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