| A Mathematical Approach to the Analysis of Multiplex DNA Profiles. | |
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MedLine Citation:
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PMID: 21103945 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Multiplex DNA profiles are used extensively for biomedical and forensic purposes. However, while DNA profile data generation is automated, human analysis of those data is not, and the need for speed combined with accuracy demands a computer-automated approach to sample interpretation and quality assessment. In this paper, we describe an integrated mathematical approach to modeling the data and extracting the relevant information, while rejecting noise and sample artifacts. We conclude with examples showing the effectiveness of our algorithms. |
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Authors:
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Robert M Goor; Lisa Forman Neall; Douglas Hoffman; Stephen T Sherry |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-20 |
Journal Detail:
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Title: Bulletin of mathematical biology Volume: - ISSN: 1522-9602 ISO Abbreviation: Bull. Math. Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401404 Medline TA: Bull Math Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA, goorrob@mail.nih.gov. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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