Document Detail

Math5 is required for both early retinal neuron differentiation and cell cycle progression.
MedLine Citation:
PMID:  16690048     Owner:  NLM     Status:  MEDLINE    
CNS progenitors choose a fate, exit mitosis and differentiate. Basic helix-loop-helix (bHLH) transcription factors are key regulators of neurogenesis, but their molecular mechanisms remain unclear. In the mouse retina, removal of the bHLH factor Math5 (Atoh7) causes the loss of retinal ganglion cells (RGCs) and appearance of excess cone photoreceptors. Here, we show a simultaneous requirement for Math5 in retinal neuron formation and cell cycle progression. At embryonic day E11.5, Math5-/- cells are unable to assume the earliest fates, particularly that of an RGC, and instead adopt the last fate as Müller glia. Concurrently, the loss of Math5 causes mitotically active retinal progenitors to undergo aberrant cell cycles. The drastic fate shift of Math5-/- cells correlates with age-specific alterations in p27/Kip1 expression and an inability to become fully postmitotic. Finally, Math5 normally suppresses NeuroD1 within Math5-expressing cells and inhibits Ngn2 expression and cone photoreceptor genesis within separate cell populations. Thus, Math5 orchestrates neurogenesis in multiple ways, regulating both intrinsic and extrinsic processes.
Tien T Le; Emily Wroblewski; Sima Patel; Amy N Riesenberg; Nadean L Brown
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-04-07
Journal Detail:
Title:  Developmental biology     Volume:  295     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-10-24     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-78     Citation Subset:  IM    
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MeSH Terms
Basic Helix-Loop-Helix Transcription Factors / analysis,  deficiency,  physiology*
Cell Cycle*
Cell Differentiation*
Cell Lineage
Cyclin-Dependent Kinase Inhibitor p27 / analysis
Embryo, Mammalian
Mice, Knockout
Nerve Tissue Proteins / analysis,  deficiency,  physiology*
Neurons / cytology*
Retina / cytology*
Stem Cells
Grant Support
R01 EY013612/EY/NEI NIH HHS; R01 EY013612-06/EY/NEI NIH HHS; R01EY13612/EY/NEI NIH HHS
Reg. No./Substance:
0/Atoh7 protein, mouse; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Nerve Tissue Proteins; 0/Neurod1 protein, mouse; 0/Neurog2 protein, mouse; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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