Document Detail

Maternally transmitted foetal H19 variants and associations with birth weight.
MedLine Citation:
PMID:  21573965     Owner:  NLM     Status:  MEDLINE    
This study was designed to test the hypothesis that polymorphic variation in maternally transmitted foetal H19 alleles is associated with offspring size at birth and alterations in maternal glucose concentrations in pregnancy. Inferred parent of origins of transmitted alleles from 13 haplotype tag SNPs in the H19 gene region from 845 family (mother, partner, offspring) trios from the prospective Cambridge Baby Growth Study and 315 trios from the retrospective Cambridge Wellbeing Study cohorts were tested for association with offspring size at birth measures, as well as maternal glucose concentrations 1 h after a glucose load at week 28 of pregnancy. The foetal rs2071094 allele inherited from the mother was associated with increased birth weight (p = 0.0015) adjusted for gestational age, parity and sex. In the Cambridge Baby Growth Study it was also associated with increased head circumference (p = 0.004), length (p = 0.017) and sum of skinfold thicknesses (p = 0.017) at birth. In contrast to these results there was no association between offspring birth weight and either the maternal rs2071094 genotype or the foetal allele from the father. None of the foetal alleles or maternal genotypes were associated with maternal glucose concentrations, neither were there any other associations with offspring birth weight. In conclusion, consistent with imprinting, common polymorphic variation in foetal H19 alleles transmitted only from the mother are associated with birth weight and other markers of size at birth. Polymorphic variation in H19 is not associated with significant changes in maternal glucose tolerance in the third trimester of pregnancy.
Clive J Petry; Rachel V Seear; Dianne L Wingate; Carlo L Acerini; Ken K Ong; Ieuan A Hughes; David B Dunger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-15
Journal Detail:
Title:  Human genetics     Volume:  130     ISSN:  1432-1203     ISO Abbreviation:  Hum. Genet.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-14     Completed Date:  2011-12-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  IM    
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MeSH Terms
Birth Weight / genetics*
Blood Glucose / genetics*
Cohort Studies
Genetic Variation
Infant, Newborn
Polymorphism, Single Nucleotide
Prospective Studies
RNA, Long Noncoding
RNA, Untranslated / genetics*
Retrospective Studies
Skinfold Thickness
Grant Support
MC_U106179472//Medical Research Council; //Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Blood Glucose; 0/H19 long non-coding RNA; 0/RNA, Long Noncoding; 0/RNA, Untranslated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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