Document Detail


Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria.
MedLine Citation:
PMID:  12543619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The consequences of pregnancy-associated malaria on a child's health have been poorly investigated. Malarial infection of the placenta seems to result in a higher susceptibility of children to the parasite during their first year of life. In 1993-1995, the authors investigated the role of antibodies in variable surface antigens (VSA) specific to chondroitin sulfate A (CSA)-binding parasites to assess the parasitologic status of the child. Flow cytometry was used to measure levels of antibodies to VSA from CSA-selected and -unselected parasite lines in the cord blood of 79 newborns in Ebolowa, Cameroon. These newborns were subsequently followed up for 2 years to determine the date of first occurrence of blood parasites and mean parasite density during follow-up. Maternally transmitted antibodies to VSA expressed by CSA-binding parasites, but not antibodies to any other specificity, were negatively related to time of first appearance of Plasmodium falciparum in a child's blood and were positively related to mean parasite density during the first 2 years of life. If maternal infection is thought to be the main mechanism influencing susceptibility of the newborn to malaria, antibodies to VSA may better denote maternal malaria infection during almost the entire pregnancy as opposed to placental blood smear reflecting infection during the last few months of pregnancy.
Authors:
Michel Cot; Jean Yves Le Hesran; Trine Staalsoe; Nadine Fievet; Lars Hviid; Philippe Deloron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  157     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-24     Completed Date:  2003-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Affiliation:
Mother and Child Health in the Tropics, Research Institute for Development, Hôpital Tenon, Paris, France. Michel.cot@ird.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Protozoan
Antigens, Protozoan / isolation & purification*
Birth Weight
Cameroon
Cohort Studies
Disease Susceptibility / immunology
Erythrocytes / parasitology
Female
Fetal Blood / parasitology*
Histocompatibility Antigens Class I / blood*
Humans
Infant, Newborn
Malaria, Falciparum / immunology*
Male
Maternal-Fetal Exchange / immunology*
Plasmodium falciparum / immunology*
Pregnancy
Pregnancy Proteins / blood*
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Antigens, Protozoan; 0/Histocompatibility Antigens Class I; 0/Pregnancy Proteins; 0/pregnancy-specific antigen, sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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