Document Detail


Maternally derived immunoglobulin light chain is present in the fetal mammalian CNS.
MedLine Citation:
PMID:  9096149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toward identifying molecules involved in cell-cell interactions during cerebral cortical development, we have investigated the nature of immunoglobulin-like immunoreactivity (Ig-ir) in the murine cortex. Immunohistochemistry using several antisera recognizing IgG revealed intense immunoreactivity in the subplate and marginal zone of embryonic day 16 cortex, as well as in the hindbrain and spinal cord, particularly within ventral fiber tracts. In three independently derived mouse strains lacking the recombination activating genes RAG-1 or RAG-2, which are essential for Ig production, Ig-ir was absent from the fetal CNS. Western blot analyses of wild-type brains from embryonic day 12 through birth identified a 25 kDa protein that co-migrated with Ig light chain and was absent from RAG-1 or RAG-2 -/- brain samples. This result could be replicated with an antiserum specific for Ig kappa light chain, but not with antisera specific for Ig gamma or mu heavy chain. No Ig-ir was detected in the brains of RAG-1 +/- embryos carried by a -/- female, suggesting a maternal source of the immunoreactive molecule. In confirmation of this, Ig-ir could be partially reproduced by intraperitoneal injection of pregnant RAG-1 -/- females with normal mouse serum. We conclude that maternally derived Ig light chain is present in the fetal murine CNS. This may represent a novel maternal contribution to fetal neural development and implicates Ig molecules as potential mediators of cortical developmental events.
Authors:
J A Weiner; J Chun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  17     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3148-56     Citation Subset:  IM    
Affiliation:
Neurosciences Graduate Program, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093-0636, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System / growth & development*,  metabolism*
Embryonic and Fetal Development*
Female
Immunoglobulin Light Chains / metabolism*
Maternal-Fetal Exchange / physiology*
Mice
Pregnancy
Chemical
Reg. No./Substance:
0/Immunoglobulin Light Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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