Document Detail

Maternal weight and weight gain during pregnancy modify the immunomodulatory potential of breast milk.
MedLine Citation:
PMID:  22453296     Owner:  NLM     Status:  Publisher    
Background:Breast milk is an optimal source of nutrition for infants and it contains bioactive components including bacteria which support the microbial colonization and immune system development of the infant. The determinants of human milk composition remain poorly understood, although maternal nutritional and immunological status as well as lifestyle and dietary habits seem to have an impact.Methods:Women were selected from a prospective follow-up study according to BMI. Milk samples were taken following delivery and 1 and 6 months later for analysis TGF-β2, soluble CD14 (sCD14), cytokines and microbiota composition.Results:TGF-β2 and sCD14 levels in the breast milk of overweight mothers tended to be lower than in normal-weight mothers, and further, higher Staphylococcus group and lower Bifidobacterium group levels were detected in overweight compared to normal-weight mothers. The prevalence of A. muciniphila-type bacteria was higher in overweight mothers, and their numbers were related to the IL6 concentration in the colostrum which was also related to lower counts of Bifidobacterium group bacteria in excessive weight women.Conclusions:Complex interactions of cytokines and microbiota in breast milk guide the microbiological, immunological, and metabolic programming of child health. Our data may indicate an additional mechanism explaining the heightened obesity risk in infants of overweight mothers.
Maria Carmen Collado; Kirsi Laitinen; Seppo Salminen; Erika Isolauri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Institute of Agrochemistry and Food Science, Spanish National Research Council (IATA-CSIC), Department of Biotechnology, 46980 Valencia, Spain [2] Functional Foods Forum, University of Turku, 20520 Turku, Finland.
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