Document Detail

Maternal vitamin d status: implications for the development of infantile nutritional rickets.
MedLine Citation:
PMID:  22525843     Owner:  NLM     Status:  In-Data-Review    
The mother is the major source of circulating 25-OHD concentrations in the young infant. Thus maternal vitamin D status is an important factor in determining the vitamin D status of the infant and his/her risk of developing vitamin D deficiency and infantile nutritional rickets. There is evidence that the supplementation recommendations, particularly for pregnant and lactating women, may be inadequate to ensure vitamin D sufficiency in these groups. Thus there needs to be a wide spread and concerted effort to ensure daily supplementation of breastfed and other infants at high risk with vitamin D 400 IU from birth and pregnant women in high risk communities with at least 600 IU. Future studies are required to determine the optimal doses of vitamin D supplementation needed during pregnancy and lactation; and for normalizing vitamin D stores in infancy to reduce the prevalence of infantile nutritional rickets. Furthermore, operational research studies need to be conducted to understand the best methods of implementing supplementation programs and the factors that are likely to promote their success.
Kebashni Thandrayen; John M Pettifor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rheumatic diseases clinics of North America     Volume:  38     ISSN:  1558-3163     ISO Abbreviation:  Rheum. Dis. Clin. North Am.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708093     Medline TA:  Rheum Dis Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-79     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
MRC Developmental Pathways for Health Research Unit, Deptartment of Pediatrics, Chris Hani Baragwanath Hospital, PO Bertsham, Johannesburg 2013, South Africa.
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