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Maternal vitamin D status, its associated factors and the course of pregnancy in Thai women.
MedLine Citation:
PMID:  22702488     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CONTEXT: There are limited data on the prevalence of vitamin D inadequacy in pregnant women living in Southeast Asia, and changes in their vitamin D status during pregnancy. OBJECTIVES: To determine the prevalence of vitamin D inadequacy, its predictive factors and the changes in vitamin D status during the course of pregnancy. DESIGN AND PATIENTS: A prospective study of 120 pregnant Thai women with gestational age<14 weeks. MEASUREMENTS: Serum 25 hydroxyvitamin D (25OHD) and clinical data were obtained at the first visit, in the second and third trimesters of pregnancy. Vitamin D inadequacy was defined as 25OHD<75 nmol/L. RESULTS: The prevalences of vitamin D inadequacy were 83.3%, 30.9% and 27.4% for the first, second and third trimesters. The independent predictors of vitamin D inadequacy in the third trimester were not drinking vitamin fortified milk (OR 11.42; 95%CI:3.12-41.86), not taking prenatal vitamins (OR 9.70; 95%CI:2.28-41.19) and having vitamin D deficiency in the first trimester (OR 10.58; 95%CI:2.89-38.80). Vitamin D deficiency was not found in women taking prenatal vitamins. However, 20 women who took at least 400 IU/d of vitamin D from prenatal vitamins still had vitamin D insufficiency in the third trimester. CONCLUSIONS: Vitamin D inadequacy is common in pregnant Thai women, especially in the first trimester. Vitamin D supplementation may be needed prior to conception and during pregnancy. For areas with abundant sun exposure like Thailand, vitamin D supplementation at 400 IU/d is likely to prevent vitamin D deficiency, but is inadequate to prevent vitamin D insufficiency even at 800 IU/d. © 2012 Blackwell Publishing Ltd.
Authors:
Natthinee Charatcharoenwitthaya; Tongta Nanthakomon; Charintip Somprasit; Athita Chanthasenanont; La-Or Chailurkit; Junya Pattaraarchachai; Boonsong Ongphiphadhanakul
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-16
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Medicine, Faculty of Medicine, Thammasat University.
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