Document Detail

Maternal vitamin D status during pregnancy and child outcomes.
MedLine Citation:
PMID:  17311057     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child.
DESIGN: Prospective study.
SETTING: Princess Anne Maternity Hospital, Southampton, UK.
SUBJECTS: A group of 596 pregnant women were recruited. A total of 466 (78%) children were examined at birth, 440 (74%) at age 9 months and 178 (30%) at age 9 years.
METHODS: Maternal 25 (OH)-vitamin D concentrations were measured in late pregnancy. Anthropometry of the child was recorded at birth, 9 months and 9 years. At 9 months, atopic eczema was assessed. At 9 years, children had an echocardiogram and a dual energy x-ray absorptiometry scan, blood pressure, arterial compliance and carotid intima-media thickness were measured and intelligence and psychological function assessed.
RESULTS: There were no associations between maternal 25(OH)-vitamin D concentrations and the child's body size or measures of the child's intelligence, psychological health or cardiovascular system. Children whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15-9.29, P=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09-26.65, P=0.038) compared to children whose mothers had a concentration of <30 nmol/l.
CONCLUSION: Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.
C R Gale; S M Robinson; N C Harvey; M K Javaid; B Jiang; C N Martyn; K M Godfrey; C Cooper;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-21
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  62     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-09     Completed Date:  2008-03-24     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  68-77     Citation Subset:  IM    
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MeSH Terms
Asthma / epidemiology,  etiology
Child Development / physiology*
Cohort Studies
Dermatitis, Atopic / epidemiology,  etiology
Infant, Newborn
Longitudinal Studies
Maternal Nutritional Physiological Phenomena / physiology*
Nutritional Status*
Pregnancy Outcome
Prospective Studies
Vitamin D / adverse effects*,  analogs & derivatives,  blood*
Vitamin D Deficiency / complications,  epidemiology
Grant Support
MC_U147574237//Medical Research Council; MC_U147585827//Medical Research Council; MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1015//Medical Research Council; U.1475.00.003.00010.02(74237)//Medical Research Council
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

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