| Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood. | |
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MedLine Citation:
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PMID: 20030662 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies indicate that prenatal vitamin D intake may protect against the development of atopic diseases in young children. Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown. OBJECTIVE: To evaluate the association between prenatal vitamin D supplementation and tolerogenic antigen-presenting cells in cord blood (CB) as determined by mRNA measurement of immunoglobulin-like transcripts (ILT)3 and ILT4. METHODS: A prospective multi-centre birth cohort was established in rural areas of five European countries. Information on maternal exposures including vitamin D intake was collected by questionnaires during pregnancy. The gene expression of ILT3 and ILT4 was analysed by real-time PCR in the CB of 927 children. Maternal vitamin D supplementation was assessed in Finland and France (n=349). RESULTS: Maternal vitamin D supplementation during pregnancy was associated with an increase in the gene expression of ILT3 (P=0.012) and ILT4 (P<0.001). This association remained significant for ILT4 (P=0.020) and showed a positive trend for the gene expression of ILT3 (P=0.059) after multivariate analysis controlling for various confounders. CONCLUSIONS: Vitamin D supplementation during pregnancy may increase the mRNA levels of ILT3 and ILT4 in CB. This finding may point towards an early induction of tolerogenic immune responses by maternal vitamin D intake. |
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Authors:
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M K Rochat; M J Ege; D Plabst; J Steinle; S Bitter; C Braun-Fahrländer; J-C Dalphin; J Riedler; M Roponen; M-R Hirvonen; G Büchele; H Renz; R Lauener; S Krauss-Etschmann; E von Mutius; |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-12-16 |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 40 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 786-94 Citation Subset: IM |
Affiliation:
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Children's Hospital, University of Munich, Lindwurmstrasse 4, Munich, Germany. mascha.rochat@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigen-Presenting Cells / immunology* Child Dietary Supplements* Europe / epidemiology Female Fetal Blood / immunology* Gene Expression* Humans Hypersensitivity, Immediate / epidemiology, immunology, prevention & control* Male Membrane Glycoproteins / genetics* Pregnancy Prospective Studies RNA, Messenger / genetics Receptors, Cell Surface / genetics* Receptors, Immunologic / genetics* Risk Factors Rural Population Vitamin D / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/LILRB2 protein, human; 0/LILRB4 protein, human; 0/Membrane Glycoproteins; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, Immunologic; 1406-16-2/Vitamin D |
| Investigator | |
Investigator/Affiliation:
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Gertraud Weiss / ; Ellen Ublagger / ; Claudia Humer / ; Manuela Russegger / ; Juha Pekkanen / ; Raija Juntunen / ; Reetta Tiihonen / ; Pekka Tiittanen / ; Kati Huttunen / ; Suvi Virtanen / ; Timo Kauppila / ; Aino Nevalainen / ; Sami Remes / ; Tomi-Pekka Tuomainen / ; Anne Karvonen / ; Mikko Lappalainen / ; Marie-Laure Dalphin / ; Dominique Vuitton / ; Renaud Piarroux / ; Gabriel Reboux / ; Sandrine Roussel / ; Bertrand Sudre / ; Michael Kabesch / ; Susanne Schmid / ; Sabina Illi / ; Nicola Korherr / ; Jon Genuneit / ; Richard Peter / ; Serdar Sel / ; Nicole Blümer / ; Petra Pfefferle / ; Bert Brunekreef / ; Ulrike Gehring / ; Gert Dockes / ; Felix H Sennhauser / ; Susanne Loeliger / ; Remo Frei / ; Caroline Roduit / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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