Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. | |
MedLine Citation:
|
PMID: 19522996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes. METHODS: Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire. RESULTS: The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results. CONCLUSION: Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood. |
Authors:
|
M Erkkola; M Kaila; B I Nwaru; C Kronberg-Kippilä; S Ahonen; J Nevalainen; R Veijola; J Pekkanen; J Ilonen; O Simell; M Knip; S M Virtanen |
Related Documents
:
|
10812586 - Dietary antioxidants for cardiovascular prevention. 2019456 - Dietary and serum carotenoids and cervical intraepithelial neoplasia. 10453176 - Criteria and recommendations for vitamin c intake. 11293466 - The role of added sugars in the diet quality of children and adolescents. 22104016 - A point-of-purchase intervention featuring in-person supermarket education affects heal... 15266976 - Variable predation regimes predict the evolution of sexual dimorphism in a population o... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 39 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-15 Completed Date: 2009-08-26 Revised Date: 2011-03-26 |
Medline Journal Info:
|
Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
|
Languages: eng Pagination: 875-82 Citation Subset: IM |
Affiliation:
|
Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland. maijaliisa.erkkola@helsinki.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
|
Adult Asthma / epidemiology*, genetics, immunology Child, Preschool Cohort Studies Dermatitis, Atopic / epidemiology, genetics, immunology Dietary Supplements / adverse effects* Female Finland / epidemiology Follow-Up Studies HLA-DQ Antigens / immunology Humans Kaplan-Meier Estimate Male Pregnancy Questionnaires Rhinitis, Allergic, Perennial / epidemiology*, genetics, immunology Rhinitis, Allergic, Seasonal / epidemiology*, genetics, immunology Vitamin D / administration & dosage, adverse effects*, immunology |
Chemical | |
Reg. No./Substance:
|
0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hair interior defect in AKR/J mice.
Next Document: Identification of two pistachio allergens, Pis v 1 and Pis v 2, belonging to the 2S albumin and 11S ...