| Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. | |
MedLine Citation:
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PMID: 19522996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes. METHODS: Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire. RESULTS: The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results. CONCLUSION: Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood. |
Authors:
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M Erkkola; M Kaila; B I Nwaru; C Kronberg-Kippilä; S Ahonen; J Nevalainen; R Veijola; J Pekkanen; J Ilonen; O Simell; M Knip; S M Virtanen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 39 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-08-26 Revised Date: 2011-03-26 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 875-82 Citation Subset: IM |
Affiliation:
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Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland. maijaliisa.erkkola@helsinki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / epidemiology*, genetics, immunology Child, Preschool Cohort Studies Dermatitis, Atopic / epidemiology, genetics, immunology Dietary Supplements / adverse effects* Female Finland / epidemiology Follow-Up Studies HLA-DQ Antigens / immunology Humans Kaplan-Meier Estimate Male Pregnancy Questionnaires Rhinitis, Allergic, Perennial / epidemiology*, genetics, immunology Rhinitis, Allergic, Seasonal / epidemiology*, genetics, immunology Vitamin D / administration & dosage, adverse effects*, immunology |
| Chemical | |
Reg. No./Substance:
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0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 1406-16-2/Vitamin D |
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