Document Detail

Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children.
MedLine Citation:
PMID:  19522996     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes.
METHODS: Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire.
RESULTS: The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results.
CONCLUSION: Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood.
M Erkkola; M Kaila; B I Nwaru; C Kronberg-Kippilä; S Ahonen; J Nevalainen; R Veijola; J Pekkanen; J Ilonen; O Simell; M Knip; S M Virtanen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  39     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-26     Revised Date:  2011-03-26    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  875-82     Citation Subset:  IM    
Division of Nutrition, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland.
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MeSH Terms
Asthma / epidemiology*,  genetics,  immunology
Child, Preschool
Cohort Studies
Dermatitis, Atopic / epidemiology,  genetics,  immunology
Dietary Supplements / adverse effects*
Finland / epidemiology
Follow-Up Studies
HLA-DQ Antigens / immunology
Kaplan-Meier Estimate
Rhinitis, Allergic, Perennial / epidemiology*,  genetics,  immunology
Rhinitis, Allergic, Seasonal / epidemiology*,  genetics,  immunology
Vitamin D / administration & dosage,  adverse effects*,  immunology
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 1406-16-2/Vitamin D

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