| Maternal vitamin D and fetal growth in early-onset severe preeclampsia. | |
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MedLine Citation:
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PMID: 21507371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Recently, vitamin D deficiency has been associated with increased risks for preeclampsia and diagnosis of early-onset, severe preeclampsia (EOSPE). The purpose of this investigation was to examine the association between vitamin D levels and small-for-gestational age (SGA) in patients with EOSPE. STUDY DESIGN: Patients with EOSPE were recruited, and demographics, outcomes, and plasma were collected. We assessed 25-hydroxyvitamin D (25[OH]D) by radioimmunoassay and reported our findings in nanograms per milliliter. Results were analyzed by Mann-Whitney U test and Spearman correlation and were reported as median (Q1-Q3). RESULTS: In patients with EOSPE (n = 56), 25(OH)D was lower in patients with SGA (16.8 ng/mL; range, 8.9-23 ng/mL) vs normal fetal growth (25.3 ng/mL; range, 16-33 ng/mL; P = .02). 25(OH)D was correlated significantly with percentile growth at delivery (ρ = 0.31; P = .02). CONCLUSION: Vitamin D is lower among patients with SGA in EOSPE than those without growth retardation. We suspect that vitamin D may impact fetal growth through placental mechanisms. |
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Authors:
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Christopher J Robinson; Carol L Wagner; Bruce W Hollis; John E Baatz; Donna D Johnson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-16 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 204 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-14 Completed Date: 2011-09-15 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 556.e1-4 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Female Fetal Development* Humans Infant, Newborn Infant, Small for Gestational Age* Pre-Eclampsia / blood* Pregnancy Severity of Illness Index Vitamin D / analogs & derivatives*, blood Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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L30 HD051408-02/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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