Document Detail

Maternal vitamin D and fetal growth in early-onset severe preeclampsia.
MedLine Citation:
PMID:  21507371     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recently, vitamin D deficiency has been associated with increased risks for preeclampsia and diagnosis of early-onset, severe preeclampsia (EOSPE). The purpose of this investigation was to examine the association between vitamin D levels and small-for-gestational age (SGA) in patients with EOSPE.
STUDY DESIGN: Patients with EOSPE were recruited, and demographics, outcomes, and plasma were collected. We assessed 25-hydroxyvitamin D (25[OH]D) by radioimmunoassay and reported our findings in nanograms per milliliter. Results were analyzed by Mann-Whitney U test and Spearman correlation and were reported as median (Q1-Q3).
RESULTS: In patients with EOSPE (n = 56), 25(OH)D was lower in patients with SGA (16.8 ng/mL; range, 8.9-23 ng/mL) vs normal fetal growth (25.3 ng/mL; range, 16-33 ng/mL; P = .02). 25(OH)D was correlated significantly with percentile growth at delivery (ρ = 0.31; P = .02).
CONCLUSION: Vitamin D is lower among patients with SGA in EOSPE than those without growth retardation. We suspect that vitamin D may impact fetal growth through placental mechanisms.
Christopher J Robinson; Carol L Wagner; Bruce W Hollis; John E Baatz; Donna D Johnson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-16
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-14     Completed Date:  2011-09-15     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556.e1-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, USA.
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MeSH Terms
Case-Control Studies
Fetal Development*
Infant, Newborn
Infant, Small for Gestational Age*
Pre-Eclampsia / blood*
Severity of Illness Index
Vitamin D / analogs & derivatives*,  blood
Young Adult
Grant Support
L30 HD051408-02/HD/NICHD NIH HHS
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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