Document Detail

Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy.
MedLine Citation:
PMID:  22034647     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested possible adverse side-effects of maternal use of folic acid-containing supplements (FACSs) during pregnancy on wheeze and asthma in early childhood. We investigated the association between maternal use of FACSs and childhood respiratory health and atopy in the first 8 yrs of life. Data on maternal use of FACSs, collected during pregnancy, were available for 3,786 children participating in the Prevention and Incidence of Asthma and Mite Allergy birth cohort study. Questionnaire data on children's respiratory and allergic symptoms were collected annually and allergic sensitisation and bronchial hyperresponsiveness (BHR) were measured at 8 yrs of age. No overall (from 1 to 8 yrs of age) associations were observed between maternal use of FACSs and (frequent) asthma symptoms, wheeze, lower respiratory tract infection, frequent respiratory tract infection and eczema. Maternal folic acid use was associated with wheeze at 1 yr of age (prevalence ratio 1.20, 95% CI 1.04-1.39), but not with wheeze at later ages. Pre-natal exposure to FACSs was not associated with sensitisation and BHR. Apart from a small increased risk of early wheeze, we observed no adverse respiratory or allergic outcomes associated with pre-natal FACSs exposure in our study population.
Marga B M Bekkers; Liset E M Elstgeest; Salome Scholtens; Annemien Haveman-Nies; Johan C de Jongste; Marjan Kerkhof; Gerard H Koppelman; Ulrike Gehring; Henriëtte A Smit; Alet H Wijga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-27
Journal Detail:
Title:  The European respiratory journal     Volume:  39     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-01     Completed Date:  2012-10-16     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1468-74     Citation Subset:  IM    
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
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MeSH Terms
Asthma / chemically induced*,  epidemiology
Bronchial Hyperreactivity / chemically induced*,  epidemiology
Child, Preschool
Cohort Studies
Dietary Supplements / adverse effects*
Eczema / chemically induced
Folic Acid / adverse effects*,  therapeutic use
Health Surveys / statistics & numerical data
Hypersensitivity / epidemiology,  etiology*
Maternal-Fetal Exchange*
Prenatal Exposure Delayed Effects / chemically induced*
Respiratory Sounds / etiology
Respiratory Tract Infections / chemically induced,  epidemiology
Vitamin B Complex / adverse effects*,  therapeutic use
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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