| Maternal use of folic acid supplements during pregnancy and childhood respiratory health and atopy: the PIAMA birth cohort study. | |
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MedLine Citation:
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PMID: 22034647 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Previous studies have suggested possible adverse side effects of maternal use of folic acid containing supplements (FACSs) during pregnancy on wheeze and asthma in early childhood.We investigated the association between maternal use of (FACSs) and childhood respiratory health and atopy in the first 8 years of life.Data on maternal use of FACSs, collected during pregnancy, were available for 3,786 children participating in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study. Questionnaire data on children's respiratory and allergic symptoms were collected annually and allergic sensitization and bronchial hyperresponsiveness (BHR) were measured at 8 years.No overall (from 1 to 8 years) associations were observed between maternal use of FACSs and (frequent) asthma symptoms, wheeze, lower respiratory tract infection (RTI), frequent RTI and eczema. Maternal folic acid use was associated with wheeze at 1 year (prevalence ratio: 1.20 (95% Confidence Interval: 1.04-1.39), but not with wheeze at later ages. Prenatal exposure to FACSs was not associated with sensitization and BHR.Apart from a small increased risk of early wheeze, we observed no adverse respiratory or allergic outcomes associated with prenatal FACSs exposure in our study population. |
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Authors:
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M B M Bekkers; L E M Elstgeest; S Scholtens; A Haveman; J C de Jongste; M Kerkhof; G H Koppelman; U Gehring; H A Smit; A H Wijga |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Utrecht University, Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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