Document Detail

Maternal use of bupropion and risk for congenital heart defects.
MedLine Citation:
PMID:  20417496     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to determine if maternal bupropion treatment in early pregnancy is associated with congenital heart defects in the infant. STUDY DESIGN: We conducted a retrospective case-control study of birth defects risk factors. Data on 6853 infants with major heart defects were compared with 5869 control infants born in 1997-2004. Bupropion exposure was defined as any reported use between 1 month before and 3 months after conception. RESULTS: Mothers of infants with left outflow tract heart defects were more likely to have reported taking bupropion than mothers of control infants (adjusted odds ratio, 2.6; 95% confidence interval, 1.2-5.7; P = .01). CONCLUSION: We identified a positive association between early pregnancy bupropion use and left outflow tract heart defects; however, the magnitude of the observed increased risk was small. Nevertheless, further studies are needed to confirm these results.
Sura Alwan; Jennita Reefhuis; Lorenzo D Botto; Sonja A Rasmussen; Adolfo Correa; Jan M Friedman;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.     Date:  2010-04-24
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Antidepressive Agents, Second-Generation / adverse effects*,  therapeutic use
Bupropion / adverse effects*,  therapeutic use
Case-Control Studies
Chi-Square Distribution
Heart Defects, Congenital / chemically induced*
Infant, Newborn
Interviews as Topic
Maternal Exposure / adverse effects*
Retrospective Studies
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 34841-39-9/Bupropion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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