| Maternal use of bupropion and risk for congenital heart defects. | |
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MedLine Citation:
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PMID: 20417496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to determine if maternal bupropion treatment in early pregnancy is associated with congenital heart defects in the infant. STUDY DESIGN: We conducted a retrospective case-control study of birth defects risk factors. Data on 6853 infants with major heart defects were compared with 5869 control infants born in 1997-2004. Bupropion exposure was defined as any reported use between 1 month before and 3 months after conception. RESULTS: Mothers of infants with left outflow tract heart defects were more likely to have reported taking bupropion than mothers of control infants (adjusted odds ratio, 2.6; 95% confidence interval, 1.2-5.7; P = .01). CONCLUSION: We identified a positive association between early pregnancy bupropion use and left outflow tract heart defects; however, the magnitude of the observed increased risk was small. Nevertheless, further studies are needed to confirm these results. |
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Authors:
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Sura Alwan; Jennita Reefhuis; Lorenzo D Botto; Sonja A Rasmussen; Adolfo Correa; Jan M Friedman; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S. Date: 2010-04-24 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 52.e1-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents, Second-Generation / adverse effects*, therapeutic use Bupropion / adverse effects*, therapeutic use Case-Control Studies Chi-Square Distribution Female Heart Defects, Congenital / chemically induced* Humans Infant, Newborn Interviews as Topic Maternal Exposure / adverse effects* Pregnancy Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 34841-39-9/Bupropion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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