Document Detail


Maternal use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), and muscular ventricular septal defects.
MedLine Citation:
PMID:  15039924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Muscular ventricular septal defects (mVSDs) are the most common congenital heart defects. Previous studies have suggested maternal use of acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), and/or fever as risk factors. We evaluated the association between mVSDs and maternal use of acetaminophen or NSAIDs adjusting for fever. METHODS: Infants with nonsyndromic mVSDs (cases) and without birth defects (controls), with gestational age > or =37 weeks and their mothers were enrolled in the National Birth Defects Prevention Study. Two exposure periods were defined: the first trimester of pregnancy, and one month before pregnancy through delivery. Mothers reporting fever or medication use at least once during either period were considered exposed. Adjusted odds ratios and 95% confidence intervals were estimated independently for each exposure period. RESULTS: The analysis included 168 cases and 692 controls. Two case groups were evaluated: all mVSD infants (n = 168) (including those with associated minor cardiac defects or noncardiac defects), and infants with isolated mVSDs (n = 133). Mothers of cases were less likely to be African-American than Caucasian (OR, 0.36; 95% CI, 0.18, 0.73). Approximately equal numbers of case mothers and control mothers (10.4 versus 9.7%, respectively) reported at least one febrile episode during the first trimester. Neither acetaminophen nor NSAID exposure was significantly associated with mVSDs. This was true for both case groups and both exposure periods. CONCLUSIONS: Significant associations were not detected between the occurrence of mVSDs and maternal use of NSAIDs or acetaminophen adjusting for maternal fever, nor were they detected between maternal fever and mVSDs.
Authors:
Mario A Cleves; Van H Savell; Sarika Raj; Weizhi Zhao; Adolfo Correa; Martha M Werler; Charlotte A Hobbs;
Related Documents :
8021024 - Estimates of the economic costs of birth defects.
17903514 - Device closure of atrial septal defects with the amplatzer septal occluder: safety and ...
8357024 - Monitoring for new multiple congenital anomalies in the search for human teratogens.
2748234 - A new type of lethal short-limbed dwarfism.
21089724 - Which is the ideal target for preterm growth?
2960714 - Seasonality of suicides: environmental, sociological and biological covariations.
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  70     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-24     Completed Date:  2004-11-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Copyright Information:
Published 2004 Wiley-Liss, Inc.
Affiliation:
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Arkansas Center for Birth Defects Research and Prevention, 11219 Financial Centre Parkway, Little Rock, AR 72211, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetaminophen / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Case-Control Studies
Female
Heart Septal Defects, Ventricular / chemically induced*
Humans
Infant, Newborn
Male
Maternal Exposure / adverse effects*
Pregnancy / drug effects*
Grant Support
ID/Acronym/Agency:
U50/CCU 613236-02/CC/CDC HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 103-90-2/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus.
Next Document:  Excess birth prevalence of Hypoplastic Left Heart syndrome in eastern Wisconsin for birth cohorts 19...