| Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. | |
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MedLine Citation:
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PMID: 11316731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As fetal overexposure to glucocorticoids has been postulated to induce intrauterine growth retardation (IUGR) in humans, we investigated the effects of maternal 50% food restriction (FR50) in rats during the last week of gestation on the hypothalamo-pituitary adrenal (HPA) axis activity in both mothers and their fetuses. In mothers, FR50 increased both the plasma corticosterone (B) level from embryonic days 19-21 and the relative adrenal weight at term. FR50 decreased at term both the maternal plasma corticosteroid-binding globulin level and placental 11beta-hydroxysteroid dehydrogenase type 2 expression. In newborns, maternal FR50 reduced body and adrenal weights, glucocorticoid and mineralocorticoid receptor expressions in the hippocampus, corticoliberin expression in the hypothalamic paraventricular nucleus, and plasma ACTH. In FR50 newborns, the plasma B level was increased at birth and decreased 2 h later. When maternal circulating B was maintained at the basal level by adrenalectomy and B supply, FR50 induced IUGR in pups and decreased placental 11beta- hydroxysteroid dehydrogenase type 2 expression at term, but did not disturb the offspring's HPA axis. These results suggest that maternal undernutrition during late gestation induces both IUGR and an overexposure of fetuses to maternal B, which disturb the development of the HPA axis. |
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Authors:
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J Lesage; B Blondeau; M Grino; B Bréant; J P Dupouy |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology Volume: 142 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-04-24 Completed Date: 2001-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 1692-702 Citation Subset: AIM; IM |
Affiliation:
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Laboratoire de Neuroendocrinologie du Développement, UPRES-EA 2701, Université de Lille 1, 59655 Villeneuve d'Ascq, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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11-beta-Hydroxysteroid Dehydrogenases Animals Animals, Newborn Body Weight Corticosterone / pharmacology* Female Fetal Growth Retardation / etiology* Fetus / drug effects* Hydroxysteroid Dehydrogenases Hypothalamo-Hypophyseal System / physiology* Nutrition Disorders / physiopathology* Organ Size Pituitary-Adrenal System / physiology* Pregnancy Pregnancy Complications / physiopathology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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50-22-6/Corticosterone; EC 1.1.-/Hydroxysteroid Dehydrogenases; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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