Document Detail


Maternal and umbilical venous adrenomedullin and nitric oxide levels in intrauterine growth restriction.
MedLine Citation:
PMID:  17674265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To verify whether adrenomedullin (AM) and nitric oxide (NO) concentrations are changed in the maternal and fetal circulation in pregnancies complicated by intrauterine growth restriction (IUGR) compared to normal pregnancies, and to determine any relationship between them. METHODS: Forty-six small for gestational age (SGA) and 34 appropriate for gestational age (AGA) infants were included in the study. Umbilical and maternal venous AM and NO concentrations were determined. RESULTS: Umbilical NO concentrations in SGA infants (mean +/- SD; 176.2 +/- 75.8 micromol/L) were significantly greater than in AGA infants (143.4 +/- 39.2 micromol/L) (p = 0.015). However, umbilical AM concentrations were similar in SGA and AGA infants with 14.2 +/- 4.4 pmol/mL and 14.5 +/- 6.2 pmol/mL, respectively (p > 0.05). There was no relationship between NO and AM levels in umbilical blood (r = 0.09, p = 0.40). No difference was found between either AM or NO levels in the maternal plasma of the two groups. CONCLUSIONS: We suggest that NO is increased in the fetoplacental circulation in SGA infants probably as a response to decreased blood flow, whereas AM is not. Additionally, increased NO in the fetoplacental circulation was found to be independent from AM secretion.
Authors:
Aysima Akturk; E Esra Onal; Yildiz Atalay; Muhittin Yurekli; Deniz Erbas; Nurullah Okumus; Canan Turkyilmaz; Suna Unal; Ebru Ergenekon; Esin Koc; Ozdemir Himmetoglu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  20     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-03     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Gazi University Medical School, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin / blood*
Adult
Delivery, Obstetric
Female
Fetal Blood*
Fetal Growth Retardation / blood*
Humans
Infant, Newborn
Infant, Small for Gestational Age
Male
Nitric Oxide / blood*
Placental Circulation
Pregnancy / blood*
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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