Document Detail

Maternal treatment with opioid analgesics and risk for birth defects.
MedLine Citation:
PMID:  21345403     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined whether maternal opioid treatment between 1 month before pregnancy and the first trimester was associated with birth defects.
STUDY DESIGN: The National Birth Defects Prevention Study (1997 through 2005) is an ongoing population-based case-control study. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIS) for birth defects categories with at least 200 case infants or at least 4 exposed case infants.
RESULTS: Therapeutic opioid use was reported by 2.6% of 17,449 case mothers and 2.0% of 6701 control mothers. Treatment was statistically significantly associated with conoventricular septal defects (OR, 2.7; 95% CI, 1.1-6.3), atrioventricular septal defects (OR, 2.0; 95% CI, 1.2-3.6), hypoplastic left heart syndrome (OR, 2.4; 95% CI, 1.4-4.1), spina bifida (OR, 2.0; 95% CI, 1.3-3.2), or gastroschisis (OR, 1.8; 95% CI, 1.1-2.9) in infants.
CONCLUSION: Consistent with some previous investigations, our study shows an association between early pregnancy maternal opioid analgesic treatment and certain birth defects. This information should be considered by women and their physicians who are making treatment decisions during pregnancy.
Cheryl S Broussard; Sonja A Rasmussen; Jennita Reefhuis; Jan M Friedman; Michael W Jann; Tiffany Riehle-Colarusso; Margaret A Honein;
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2011-02-23
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-06-28     Revised Date:  2011-12-16    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314.e1-11     Citation Subset:  AIM; IM    
Copyright Information:
Published by Mosby, Inc.
Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
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MeSH Terms
Abnormalities, Drug-Induced*
Analgesics, Opioid / administration & dosage,  adverse effects*
Anterior Chamber / abnormalities
Case-Control Studies
Codeine / administration & dosage,  adverse effects
Gastroschisis / chemically induced,  epidemiology
Glaucoma / chemically induced,  epidemiology
Heart Defects, Congenital / chemically induced,  epidemiology
Hydrocephalus / chemically induced,  epidemiology
Hydrocodone / administration & dosage,  adverse effects
Infant, Newborn
Meperidine / administration & dosage,  adverse effects
Multivariate Analysis
Oxycodone / administration & dosage,  adverse effects
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects*
Pulmonary Valve Stenosis / chemically induced,  epidemiology
Spinal Dysraphism / chemically induced,  epidemiology
Grant Support
U50/CCU113247//PHS HHS; U50/CCU223184//PHS HHS; U50/CCU422096//PHS HHS; U50/CCU613232//PHS HHS; U50/CCU613236//PHS HHS; U50/CCU713238//PHS HHS; U50/CCU822097//PHS HHS; U50/CCU913241//PHS HHS
Reg. No./Substance:
0/Analgesics, Opioid; 125-29-1/Hydrocodone; 57-42-1/Meperidine; 76-42-6/Oxycodone; 76-57-3/Codeine
Comment In:
Am J Obstet Gynecol. 2011 Sep;205(3):e10; author reply e10 -1   [PMID:  22071072 ]
Am J Obstet Gynecol. 2011 Sep;205(3):e12; author reply e12-3   [PMID:  21640965 ]
Am J Obstet Gynecol. 2011 Sep;205(3):e9-e10; author reply e10-1   [PMID:  22071073 ]
Am J Obstet Gynecol. 2011 Apr;204(4):281-2   [PMID:  21458621 ]

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