Document Detail


Maternal transmission of congenital heart diseases: new recurrence risk figures and the questions of cytoplasmic inheritance and vulnerability to teratogens.
MedLine Citation:
PMID:  3812316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A review of 8 studies involving 3,996 offspring of parents who have congenital heart disease revealed that the risk for all defects was substantially higher if the affected parent was the mother rather than the father. The risk ratio ranged from a high of 6.39 for aortic stenosis to a low of 1.48 for patent ductus arteriosus, and the ratio was statistically significant in aortic stenosis (p = 0.025) and ventricular septal defect (p less than 0.001). Despite the relatively large number of cases, there were still too few patients to reveal statistical significance for a malformation such as atrioventricular canal, in which there were 5 affected offspring among 36 children of mothers who had atrioventricular canal and no affected children among 16 offspring of affected fathers (p = 0.12). The possible reasons for the preponderance of affected offspring of mothers with a congenital heart disease was studied in the context of various modes of inheritance and maternal physiology. The preliminary conclusion is that although many familial cases of congenital heart disease are compatible with multifactorial inheritance and vulnerability to teratogens, an important subset of cases, particularly in some high-risk families, may be better explained by cytoplasmic inheritance than by multifactorial or mendelian modes. Current genetic counseling should take into account the differences in risk to offspring of affected mothers while confirmation and further investigation proceeds.
Authors:
J J Nora; A H Nora
Related Documents :
3831396 - Mass survey for coronary lesions in school children with history of kawasaki disease in...
11247806 - Optical mapping of activation patterns in an animal model of congenital heart block.
16919006 - Current treatment options in children with pulmonary arterial hypertension and experien...
9020696 - Crouzon's disease correlates with low fibroblastic growth factor receptor activity in s...
17346296 - Is neonatal phototherapy associated with an increased risk for hospitalized childhood b...
3462896 - Short term effect of mechanical plaque control on salivary concentration of s. mutans a...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  59     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-23     Completed Date:  1987-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / genetics
Extrachromosomal Inheritance*
Female
Heart Defects, Congenital / genetics*
Humans
Infant, Newborn
Male
Pedigree
Recurrence
Risk
Teratogens
Chemical
Reg. No./Substance:
0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Surgical and medical results of complete atrioventricular canal: a ten year review.
Next Document:  Cardiac mechanics and function in obese normotensive persons with normal coronary arteries.