| Maternal trans fatty acid intake and fetal growth. | |
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MedLine Citation:
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PMID: 21918217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is unclear from previous studies whether total or common subtypes of trans fatty acids are associated with fetal growth. OBJECTIVE: We examined associations of maternal trans fatty acid intake during pregnancy with fetal growth. DESIGN: We studied 1369 mother-child pairs participating in Project Viva-a prospective cohort study of pregnant women and their offspring. We assessed trans fatty acid consumption by using a validated semiquantitative food-frequency questionnaire in each of the first and second trimesters of pregnancy. We estimated fetal growth as the birth-weight-for-gestational-age (BW/GA) z value in infants born at term. RESULTS: We observed no associations of first-trimester trans fatty acid consumption with fetal growth. In the second trimester, the estimated mean (±SD) total trans fatty acid intake was 2.35 ± 1.07 g/d, of which 0.11 g was 16:1(n-7t), 1.78 g was 18:1(n-9t), 0.13 g was 18:2(n-6tt), 0.33 g was 18:2(n-6tc), and 0.12 g was 18:2(n-6ct). The mean (±SD) BW/GA was 0.24 ± 0.95 z score units. Total trans fatty acid consumption during the second trimester was positively associated with the fetal growth z score (0.29 units; 95% CI: 0.07, 0.51 units) for each 1% increment in energy from trans fatty acids as a replacement for carbohydrates. The associations were limited to the trans fatty acids 16:1t (0.12 units; 95% CI: 0.02, 0.22 units) and 18:2tc (0.53 units; 95% CI: 0.09, 0.96 units). CONCLUSION: A higher maternal intake of trans fatty acids, especially 16:1t and 18:2tc, during the second trimester of pregnancy was associated with greater fetal growth. |
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Authors:
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Juliana F W Cohen; Sheryl L Rifas-Shiman; Eric B Rimm; Emily Oken; Matthew W Gillman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-09-14 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 94 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-21 Completed Date: 2012-02-01 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1241-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. jcohen@hsph.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight
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physiology* Cohort Studies Female Fetal Development / physiology* Humans Infant, Newborn Linear Models Multivariate Analysis Pregnancy / metabolism* Pregnancy Trimester, First Pregnancy Trimester, Second Prospective Studies Questionnaires Trans Fatty Acids / administration & dosage*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD 34568/HD/NICHD NIH HHS; HL 64925/HL/NHLBI NIH HHS; HL 68041/HL/NHLBI NIH HHS; K24 HD069408-02/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Trans Fatty Acids |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2012 Apr;95(4):984-5; author reply 985-6
[PMID:
22434601
]
Am J Clin Nutr. 2012 Apr;95(4):986-7; author reply 987-8 [PMID: 22434602 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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