Document Detail

Maternal trans fatty acid intake and fetal growth.
MedLine Citation:
PMID:  21918217     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is unclear from previous studies whether total or common subtypes of trans fatty acids are associated with fetal growth.
OBJECTIVE: We examined associations of maternal trans fatty acid intake during pregnancy with fetal growth.
DESIGN: We studied 1369 mother-child pairs participating in Project Viva-a prospective cohort study of pregnant women and their offspring. We assessed trans fatty acid consumption by using a validated semiquantitative food-frequency questionnaire in each of the first and second trimesters of pregnancy. We estimated fetal growth as the birth-weight-for-gestational-age (BW/GA) z value in infants born at term.
RESULTS: We observed no associations of first-trimester trans fatty acid consumption with fetal growth. In the second trimester, the estimated mean (±SD) total trans fatty acid intake was 2.35 ± 1.07 g/d, of which 0.11 g was 16:1(n-7t), 1.78 g was 18:1(n-9t), 0.13 g was 18:2(n-6tt), 0.33 g was 18:2(n-6tc), and 0.12 g was 18:2(n-6ct). The mean (±SD) BW/GA was 0.24 ± 0.95 z score units. Total trans fatty acid consumption during the second trimester was positively associated with the fetal growth z score (0.29 units; 95% CI: 0.07, 0.51 units) for each 1% increment in energy from trans fatty acids as a replacement for carbohydrates. The associations were limited to the trans fatty acids 16:1t (0.12 units; 95% CI: 0.02, 0.22 units) and 18:2tc (0.53 units; 95% CI: 0.09, 0.96 units).
CONCLUSION: A higher maternal intake of trans fatty acids, especially 16:1t and 18:2tc, during the second trimester of pregnancy was associated with greater fetal growth.
Juliana F W Cohen; Sheryl L Rifas-Shiman; Eric B Rimm; Emily Oken; Matthew W Gillman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-14
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  94     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-21     Completed Date:  2012-02-01     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-7     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight / physiology*
Cohort Studies
Fetal Development / physiology*
Infant, Newborn
Linear Models
Multivariate Analysis
Pregnancy / metabolism*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prospective Studies
Trans Fatty Acids / administration & dosage*,  metabolism
Grant Support
Reg. No./Substance:
0/Trans Fatty Acids
Comment In:
Am J Clin Nutr. 2012 Apr;95(4):986-7; author reply 987-8   [PMID:  22434602 ]
Am J Clin Nutr. 2012 Apr;95(4):984-5; author reply 985-6   [PMID:  22434601 ]

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