Document Detail

Maternal trace elements, vitamin B12, vitamin A, folic acid, and fetal malformations.
MedLine Citation:
PMID:  10080300     Owner:  NLM     Status:  MEDLINE    
The demonstrated teratogenicity of maternal zinc deficiency in rats has led to burgeoning interest in zinc and other trace elements as important factors in embryonic development. Levels of zinc, copper, manganese, magnesium, folic acid, vitamin B12 and vitamin A were evaluated at the beginning of pregnancy in the plasma of pregnant women who later delivered a malformed newborn. Fetal chromosomal anomalies and recognizable nonchromosomal syndromes were excluded. The results were compared to control women who delivered normal babies. One hundred seventy mothers had malformed children. The more frequent congenital malformations were congenital heart diseases (72 cases including 24 VSD), musculoskeletal malformations (21 cases), urogenital malformations (23 cases), spina bifida (6 cases), hydrocephaly (6 cases), and labial cleft (14 cases). Maternal plasma concentrations of zinc, copper, magnesium, manganese, folate, vitamin B12, and vitamin A of malformed children did not differ from controls. Thus vitamin profiles do not form a suitable means for identifying women at risk for having a child with congenital malformations.
C Stoll; B Dott; Y Alembik; C Koehl
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  13     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-05-11     Completed Date:  1999-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
Service de Génétique Médicale, Institut de Chimie Biologique Centre Hospitalo-Universitaire, Strasbourg, France.
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MeSH Terms
Congenital Abnormalities / blood,  etiology*
Copper / blood
Folic Acid / blood*
Magnesium / blood
Manganese / blood
Pregnancy / blood*
Trace Elements / blood*
Vitamin A / blood*
Vitamin A Deficiency / blood,  complications
Vitamin B 12 / blood*
Vitamin B Deficiency / blood,  complications
Zinc / blood
Reg. No./Substance:
0/Trace Elements; 11103-57-4/Vitamin A; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; 7439-95-4/Magnesium; 7439-96-5/Manganese; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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