Document Detail


Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring.
MedLine Citation:
PMID:  19794196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology.
AIMS: To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring psychotic symptoms.
METHOD: A longitudinal study of 6356 adolescents, age 12, who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.
RESULTS: Frequency of maternal tobacco use during pregnancy was associated with increased risk of suspected or definite psychotic symptoms (adjusted odds ratio 1.20, 95% CI 1.05-1.37, P = 0.007). Maternal alcohol use showed a non-linear association with psychotic symptoms, with this effect almost exclusively in the offspring of women drinking >21 units weekly. Maternal cannabis use was not associated with psychotic symptoms. Results for paternal smoking during pregnancy and maternal smoking post-pregnancy lend some support for a causal effect of tobacco exposure in utero on development of psychotic experiences.
CONCLUSIONS: These findings indicate that risk factors for development of non-clinical psychotic experiences may operate during early development. Future studies of how in utero exposure to tobacco affects cerebral development and function may lead to increased understanding of the pathogenesis of psychotic phenomena.
Authors:
Stanley Zammit; Kate Thomas; Andrew Thompson; Jeremy Horwood; Paulo Menezes; David Gunnell; Chris Hollis; Dieter Wolke; Glyn Lewis; Glynn Harrison
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  195     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-01     Completed Date:  2009-12-16     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  294-300     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alcohol Drinking / epidemiology*,  psychology
Cannabis / adverse effects
Child
Dose-Response Relationship, Drug
Epidemiologic Methods
Female
Humans
Male
Marijuana Abuse / epidemiology*,  psychology
Maternal Exposure / adverse effects
Pregnancy
Pregnancy Trimesters
Prenatal Exposure Delayed Effects*
Psychotic Disorders / epidemiology*
Smoking / epidemiology*,  psychology
Grant Support
ID/Acronym/Agency:
G9815508//Medical Research Council; GR072043MA//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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