| Maternal thyroid function in early and late pregnancy. | |
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MedLine Citation:
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PMID: 1823079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyroid function was investigated during and after pregnancy in 12 healthy euthyroid women. During pregnancy, serum total T4 (TT4) levels were significantly elevated and nearly stable, while thyroxine-binding globulin (TBG) levels progressively increased till the 7th month. A slight elevation, though not significant, of free T4 (fT4) was recorded in early pregnancy. In the following months, fT4, free T3 (fT3) and the T4/TBG ratio progressively diminished, reaching a plateau at the 7th month. Serum TSH levels, measured by an ultrasensitive immunofluorometric assay, were comparable to postpartum values during the first trimester and showed a moderate upward trend with the progression of pregnancy. The evaluation of 24-hour TSH profiles was performed in 5 women during the first trimester of pregnancy. In all women, the circadian rhythm of TSH was present with a normal nocturnal surge, though anticipated in 1 case. In summary (1) during the first trimester of pregnancy, the increased thyroid activity does not seem to be only sustained by pituitary TSH which remains unmodified; the negative correlation between TSH and hCG levels might suggest that hCG also stimulates the gland to increase thyroid hormone output, and the presence of a normal TSH circadian rhythm indicates that the central mechanism of neuroregulation of the pituitary-thyroid axis is preserved in early pregnancy, and (2) in late pregnancy, a marked decrease in free thyroid hormone fractions is accompanied by serum TSH levels still in the normal range, indicating a modification of thyroid homeostasis which might recognize various etiological factors. |
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Authors:
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M Nissim; G Giorda; M Ballabio; A D'Alberton; D Bochicchio; R Orefice; G Faglia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hormone research Volume: 36 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-09-15 Completed Date: 1992-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 196-202 Citation Subset: IM |
Affiliation:
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Italian Auxologic Center, IRCCS, University of Milan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / blood Circadian Rhythm Female Humans Postpartum Period / physiology Pregnancy / physiology* Thyroid Gland / physiology* Thyrotropin / blood Thyroxine / blood Thyroxine-Binding Proteins / metabolism Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Thyroxine-Binding Proteins; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
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