Document Detail

Maternal thyroid function in early and late pregnancy.
MedLine Citation:
PMID:  1823079     Owner:  NLM     Status:  MEDLINE    
Thyroid function was investigated during and after pregnancy in 12 healthy euthyroid women. During pregnancy, serum total T4 (TT4) levels were significantly elevated and nearly stable, while thyroxine-binding globulin (TBG) levels progressively increased till the 7th month. A slight elevation, though not significant, of free T4 (fT4) was recorded in early pregnancy. In the following months, fT4, free T3 (fT3) and the T4/TBG ratio progressively diminished, reaching a plateau at the 7th month. Serum TSH levels, measured by an ultrasensitive immunofluorometric assay, were comparable to postpartum values during the first trimester and showed a moderate upward trend with the progression of pregnancy. The evaluation of 24-hour TSH profiles was performed in 5 women during the first trimester of pregnancy. In all women, the circadian rhythm of TSH was present with a normal nocturnal surge, though anticipated in 1 case. In summary (1) during the first trimester of pregnancy, the increased thyroid activity does not seem to be only sustained by pituitary TSH which remains unmodified; the negative correlation between TSH and hCG levels might suggest that hCG also stimulates the gland to increase thyroid hormone output, and the presence of a normal TSH circadian rhythm indicates that the central mechanism of neuroregulation of the pituitary-thyroid axis is preserved in early pregnancy, and (2) in late pregnancy, a marked decrease in free thyroid hormone fractions is accompanied by serum TSH levels still in the normal range, indicating a modification of thyroid homeostasis which might recognize various etiological factors.
M Nissim; G Giorda; M Ballabio; A D'Alberton; D Bochicchio; R Orefice; G Faglia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone research     Volume:  36     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1992-09-15     Completed Date:  1992-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  196-202     Citation Subset:  IM    
Italian Auxologic Center, IRCCS, University of Milan.
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MeSH Terms
Chorionic Gonadotropin / blood
Circadian Rhythm
Postpartum Period / physiology
Pregnancy / physiology*
Thyroid Gland / physiology*
Thyrotropin / blood
Thyroxine / blood
Thyroxine-Binding Proteins / metabolism
Triiodothyronine / blood
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Thyroxine-Binding Proteins; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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