Document Detail

Maternal thyroid function during pregnancy and parent-report problem behavior of the offspring up to age three years. The Generation R Study.
MedLine Citation:
PMID:  21283053     Owner:  NLM     Status:  Publisher    
Maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. We investigated the association of maternal thyroid function during the first half of pregnancy with parent reported problem behavior of the offspring up to age three years. In the Generation R Study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's behavior were examined. The degree of Internalizing and externalizing problems in the children were assessed with the Child Behavior Checklist at ages 1½ and 3 years. Higher levels of maternal TSH during pregnancy predicted a higher externalizing scores in children at 1½ and 3 years (B=0.22 per SD of TSH, 95% CI: 0.04, 0.40; B=0.10 per SD for internalizing scores, 95% CI: -0.01, 0.21).Maternal Free T4 (thyroxine) and total T4 were not associated with internalizing or externalizing scores of children. The linear relation with more externalizing scores was across the range of TSH; this implies that subtle impairments of maternal thyroid function may affect the child. The results suggest that thyroid function is crucial for fetal brain development, which determines problem behavior later in life. ABBREVIATIONS::
Akhgar Ghassabian; Jacoba J Bongers-Schokking; Jens Henrichs; Vincent W V Jaddoe; Theo J Visser; Willy Visser; Sabine M P F de Muinck Keizer-Schrama; Herbert Hooijkaas; Eric A P Steegers; Albert Hofman; Frank C Verhulst; Jan van den Ende; Yolanda B de Rijke; Henning Tiemeier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-28
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Child and Adolescent Psychiatry [A.G, F.C.V., J.E., H.T.], and Clinical Chemistry [Y.B.R], Erasmus MC - Sophia Children's Hospital, Rotterdam, 3000 CB, the Netherlands; Departments of Endocrinology [J.J.B.-S., S.M.P.F.M.K.-S.], Pediatrics [V.W.V.J], Epidemiology [V.W.V.J, A.H., H.T.], Internal Medicine [T.J.V., Y.B.R.], Obstetrics and Gynecology [W.V., E.A.P.S.], and Immunology [H.H.], Erasmus MC - Sophia Children's Hospital, Rotterdam 3000 CA, the Netherlands; Institute of Psychology [J.H.], Erasmus University, Rotterdam, 3000 DR, the Netherlands.
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