Document Detail

Maternal thyroid function at 11-13 weeks of gestation and spontaneous preterm delivery.
MedLine Citation:
PMID:  21252742     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To estimate the possible association between spontaneous early preterm delivery and maternal thyroid dysfunction in early pregnancy.
METHODS: : Maternal serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine, antithyroperoxidase, and antithyroglobulin antibodies at 11-13 weeks of gestation were compared in 102 singleton pregnancies, resulting in spontaneous delivery before 34 weeks and 4,318 normal pregnancies delivering after this gestation.
RESULTS: : In the preterm delivery group, compared with the normal outcome group, there was no significant difference in antithyroid antibody positivity (16.7% compared with 16.8%). In the antithyroid antibody-negative pregnancies in the preterm delivery group, compared with the normal outcome group, the median free thyroxine multiple of the median was reduced (0.94 compared with 0.99 multiple of the median, P<.001), but the median TSH multiple of the median was not significantly different (0.99 compared with 1.01 multiple of the median, P=.331).
CONCLUSION: : In pregnancies resulting in spontaneous early preterm delivery, there is no evidence of increased prevalence of antithyroid antibody positivity or maternal thyroid dysfunction at 11-13 weeks.
Ghalia Ashoor; Nerea Maiz; Michael Rotas; Firas Jawdat; Kypros H Nicolaides
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  117     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  AIM; IM    
From the Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK; the Department of Fetal Medicine, University College Hospital, London, UK; and Unidad Medicina Fetal, Centro Sanitario Virgen del Pilar, San Sebastián, Spain.
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