| Maternal thromboxane and prostacyclin levels in relation to fetal birth weight. | |
| | |
MedLine Citation:
|
PMID: 11000507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To analyse whether pregnancies resulting in a small for gestational age neonate are preceded by a prostacyclin deficiency or an imbalance between thromboxane and prostacyclin. STUDY DESIGN: At five fixed time points during pregnancy, 24-h urine samples were collected for the measurement of thromboxane and prostacyclin metabolites thromboxane-B(2) (TXB(2)) and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)). In order to study trend differences between pregnancies with appropriate (AGA; n=26) and small for gestational age neonates (SGA; n=17), trend analysis with simple contrasts were accomplished for TXB(2), 6-keto-PGF(1alpha) and the TXB(2)/6-keto-PGF(1alpha) ratio. RESULTS: Trend analysis showed higher TXB(2) levels and higher TXB(2)/6-keto-PGF(1alpha) ratios in patients with SGA versus AGA newborns. No statistically significant difference in 6-keto-PGF(1alpha) excretion between patients with SGA and AGA newborns was detected. CONCLUSION: The birth of an SGA neonate is not preceded by prostacyclin deficiency. With ongoing pregnancy an imbalance between thromboxane and prostacyclin becomes more obvious in pregnancies with SGA newborns. |
| | |
Authors:
|
C L de Jong; K M Paarlberg; H P van Geijn; G J van Kamp; H van Dis; G A Dekker |
Related Documents
:
|
21422007 - 'forbidden points' in pregnancy: do they exist? 21267227 - Preventing teenage pregnancy: a team approach. 1269307 - A study of the "inversion of intensity" between newborn and preschool-age behavior. 22969887 - Association of slc38a4 and system a with abnormal fetal birth weight. 2133907 - Vertical transmission of hbsag in alexandria. 17096217 - Laboratory reconstructions of real world frontal crash configurations using the hybrid ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 93 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2000-11-15 Completed Date: 2000-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 65-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Postbus 7057, 1007 MB, Amsterdam, The Netherlands. dejong-speelman@wxs.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
6-Ketoprostaglandin F1 alpha
/
blood* Adult Birth Weight* Female Gestational Age Humans Infant, Newborn Infant, Small for Gestational Age* Pre-Eclampsia / blood Pregnancy Thromboxane B2 / blood* |
| Chemical | |
Reg. No./Substance:
|
54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oral analgesia in the treatment of post-cesarean pain.
Next Document: Usefulness of human papilloma virus testing in the screening of cervical cancer precursor lesions: a...