| Maternal thrombophilia and neonatal thrombosis. | |
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MedLine Citation:
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PMID: 12763496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In neonates and infants, numerous clinical and environmental conditions lead to elevated thrombin generation and subsequent thrombus formation. Genetic prothrombotic defects (protein C, protein S and antithrombin deficiency, mutations of coagulation factor V and factor II, elevated lipoprotein (a)) have been established as risk factors of thromboembolic events in neonates and infants. The interpretation of the laboratory evaluation relies on age-dependent normal reference values. Because appropriate clinical trials are missing in these age groups, treatment recommendations are adapted from small-scale studies in neonates and infants and from guidelines relating to adult patient protocols. Secondary long-term anticoagulation should be administered on an individual basis. |
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Authors:
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Christine Heller; Ulrike Nowak-Göttl |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical haematology Volume: 16 ISSN: 1521-6926 ISO Abbreviation: Best Pract Res Clin Haematol Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-23 Completed Date: 2004-03-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 101120659 Medline TA: Best Pract Res Clin Haematol Country: England |
Other Details:
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Languages: eng Pagination: 333-45 Citation Subset: IM |
Affiliation:
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Paediatric Haematology/Oncology, University Hospital of Frankfurt, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fibrinolytic Agents / therapeutic use Humans Infant, Newborn Infant, Newborn, Diseases / diagnosis, drug therapy, etiology Pregnancy Prenatal Diagnosis Risk Factors Thrombophilia / complications* Thrombosis / diagnosis, drug therapy, etiology* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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