Document Detail

Maternal thrombophilia and neonatal thrombosis.
MedLine Citation:
PMID:  12763496     Owner:  NLM     Status:  MEDLINE    
In neonates and infants, numerous clinical and environmental conditions lead to elevated thrombin generation and subsequent thrombus formation. Genetic prothrombotic defects (protein C, protein S and antithrombin deficiency, mutations of coagulation factor V and factor II, elevated lipoprotein (a)) have been established as risk factors of thromboembolic events in neonates and infants. The interpretation of the laboratory evaluation relies on age-dependent normal reference values. Because appropriate clinical trials are missing in these age groups, treatment recommendations are adapted from small-scale studies in neonates and infants and from guidelines relating to adult patient protocols. Secondary long-term anticoagulation should be administered on an individual basis.
Christine Heller; Ulrike Nowak-Göttl
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  16     ISSN:  1521-6926     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-23     Completed Date:  2004-03-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-45     Citation Subset:  IM    
Paediatric Haematology/Oncology, University Hospital of Frankfurt, Germany.
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MeSH Terms
Fibrinolytic Agents / therapeutic use
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  drug therapy,  etiology
Prenatal Diagnosis
Risk Factors
Thrombophilia / complications*
Thrombosis / diagnosis,  drug therapy,  etiology*
Reg. No./Substance:
0/Fibrinolytic Agents

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