Document Detail


Maternal supply of BDNF to mouse fetal brain through the placenta.
MedLine Citation:
PMID:  19114070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastrointestinal peptides and hormones are known to penetrate through the utero-placental barrier and regulate fetal development. In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuses, using BDNF-gene deficient mice and exogenous BDNF administration. At embryonic day 13.5 (E13.5)-14.5, BDNF protein concentrations in the fetal brain of BDNF homozygous null mutant (bdnf (-/-)) were comparable to the levels seen in wild-type fetuses. After E17.5, BDNF protein levels in bdnf (-/-) fetal brain were still detectable but its levels were significantly decreased below those in wild-type brain. When recombinant BDNF protein was injected into pregnant wild-type mice carrying E14.5 embryos, BDNF protein levels in fetal brain were elevated dose-dependently. These findings suggest that maternal BDNF reaches the fetal brain through utero-placental barrier and might contribute to its development.
Authors:
Ikuko Kodomari; Etsuko Wada; Shun Nakamura; Keiji Wada
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-09
Journal Detail:
Title:  Neurochemistry international     Volume:  54     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2009-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Affiliation:
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Brain-Derived Neurotrophic Factor / genetics,  metabolism*,  pharmacology
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Female
Fetus / metabolism*
Genotype
Maternal-Fetal Exchange / physiology*
Mice
Mice, Knockout
Placenta / metabolism*
Pregnancy
RNA, Messenger / biosynthesis,  genetics
Recombinant Proteins / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/RNA, Messenger; 0/Recombinant Proteins

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