Document Detail


Maternal social stress modulates the development of prepulse inhibition of startle in infants.
MedLine Citation:
PMID:  23245223     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Stress during rearing has negative effects on the maturation of information processing in rodent offspring, but similar evidence in humans is absent. Prepulse inhibition (PPI) of startle is a measure reflecting the integrity of information processing. PPI does not depend on active cooperation, making it a suitable measure for studying newborns and infants. This study investigated whether postnatal development of infant PPI is influenced by self-reported stress in the mother.
METHODS: 49 healthy term-born infants were studied twice, four days after birth and again at four months. PPI was assessed by presentation of acoustic startle stimuli (95dB) either alone or preceded (SOA 120ms) by a prepulse (75dB). Mother's social stress levels were assessed with the modified Trier Inventory for the Assessment of Chronic Stress (TICS). Cortisol saliva samples were collected from mothers and their children.
RESULTS: ANOVA revealed a different development of PPI in infants whose mothers reported enhanced stress levels due to social isolation and reduced social recognition. Cortisol levels were related to mothers' self-report stress, but not to PPI development in infants.
CONCLUSIONS: Maternal stress experience has an impact on the maturation of human infants' information processing in the first four months after birth.
Authors:
Harriet J Huggenberger; Susanne E Suter; Terry D Blumenthal; Hartmut Schachinger
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Publication Detail:
Type:  Journal Article     Date:  2012-09-27
Journal Detail:
Title:  Developmental cognitive neuroscience     Volume:  3     ISSN:  1878-9307     ISO Abbreviation:  Dev Cogn Neurosci     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101541838     Medline TA:  Dev Cogn Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Psychology, University of Basel, NCCR sesam, Basel, Switzerland. Electronic address: hhuggenberger@uhbs.ch.
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