Document Detail

Maternal smoking and sudden infant death syndrome: epidemiological study related to pathology.
MedLine Citation:
PMID:  17091255     Owner:  NLM     Status:  MEDLINE    
Various risk factors have been postulated to be related to sudden infant death syndrome (SIDS). Despite its reduction, thanks to the "Back to Sleep" campaign, SIDS is still a major cause of infant mortality in the first year of life. The purpose of this study was to correlate the different risk factors with the autopsy results and thus to determine if one or more of these variables is really specific for SIDS. We collected 128 sudden infant death victims with clinical diagnosis of SIDS and performed a complete autopsy with in-depth histology on serial sections, particularly of the brainstem, in accordance with our necropsy protocol. Histopathologic and immunohistochemical examination of the central autonomic nervous system revealed, in 78 cases of the SIDS group, the following anomalies: hypodevelopment of the arcuate nucleus, somatostatin positive hypoglossus nucleus, tyrosine hydroxylase negativity in the locus coeruleus, gliosis, and hypoplasia of the hypoglossus nucleus. A significant relation was found between maternal smoke and brainstem alterations.
Luigi Matturri; Giulia Ottaviani; Anna Maria Lavezzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-08
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  449     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-24     Completed Date:  2007-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  697-706     Citation Subset:  IM    
Institute of Pathology, University of Milan, Via della Commenda, 19, 20122 Milan, Italy.
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MeSH Terms
Air Pollution / adverse effects
Arcuate Nucleus / pathology
Brain Stem / pathology*
Prone Position
Risk Factors
Smoking / adverse effects*
Sudden Infant Death / etiology*,  pathology*

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