Document Detail

Maternal smoking in relation to the incidence of early neonatal jaundice.
MedLine Citation:
PMID:  2920968     Owner:  NLM     Status:  MEDLINE    
A case-control study was carried out to investigate the association between maternal smoking during pregnancy and the risk of early neonatal jaundice. A total of 1,569 cases of neonatal jaundice (2.7% of all singleton births) were identified from the 1984 Washington State birth certificates as having a bilirubin level greater than 10 mg/dl within the first 2 days of life. 2,336 nonjaundiced infants were randomly selected to serve as controls. Information regarding smoking during pregnancy was also obtained from the birth certificates. After excluding infants with known risk factors for neonatal jaundice, 912 cases and 1,752 controls were available for analyses. Infants whose mother smoked cigarettes during pregnancy were at lower risk of neonatal jaundice (odds ratio = 0.81; 95% confidence interval = 0.66-0.99) relative to infants of nonsmokers. This relative risk changed very little after adjusting separately for maternal age, infant's gender, number of prior pregnancies, number of prenatal visits, marital status and number of prior fetal deaths. There was suggestive evidence that this apparent protective effect may be operating only among normal and high-birth-weight infants.
A study of the relationship between maternal smoking and the risk of neonatal jaundice found that infants who had been born of mothers who smoked had less of a chance of neonatal jaundice. This relationship was not affected by such factors as race and age, infant sex, reproductive history, delivery methods and other factors. 912 cases and 1752 control infants without jaundice were examined. However, the study was limited to cases of jaundice which had been observed in the 1st days of life. Therefore, conclusions were drawn solely from white infants with jaundice diagnosed early on. It was also found that breast-feeding increased the risk of jaundice. Another recent study had conflicting results. It found that 1700 mostly black mothers of a lower socioeconomic status had an increased risk of jaundice with smoking more than 1/2 a pack of cigarettes/day. This was attributed to the discrepancy in race and socioeconomic status among the 2 study groups. The properties of cigarette smoke and their physical effects on infants are discussed.
V K Diwan; T L Vaughan; C Y Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  27     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1989  
Date Detail:
Created Date:  1989-04-12     Completed Date:  1989-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  22-5     Citation Subset:  IM; J    
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle.
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MeSH Terms
Bilirubin / blood
Birth Weight
Infant, Newborn
Jaundice, Neonatal / blood,  epidemiology*
Risk Factors
Reg. No./Substance:

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