Document Detail

Maternal smoking in pregnancy and sex differences in perinatal death between boys and girls.
MedLine Citation:
PMID:  10085739     Owner:  NLM     Status:  MEDLINE    
The sex difference in perinatal mortality in developed countries is largely unexplained. The current study evaluated the differences in the impact of maternal smoking during pregnancy on the risk of perinatal death between males and females. The analysis involved 11,469 and 9,404 newborns derived from two population-based birth cohorts in Northern Finland, for 1966 and 1985-86, respectively. The perinatal mortality rate was 23 per thousand in the 1966 cohort and 9 per thousand in the 1985-86 cohort. The rate ratio (RR) for mortality for males over females is 1.15 and 1.60 in the two cohorts, respectively. Among children whose mothers smoked during pregnancy, the RR was 2.2 (95% CI 1.0, 4.7) for the former cohort and 4.8 (95% CI 1.5, 15.2) for the later cohort; and among the children whose mothers did not smoke the corresponding RR was 1.2 (95% CI 0.9, 1.6) and 1.1 (95% CI 0.6, 1.9). Maternal smoking during pregnancy could be an important determinant accounting for the excess perinatal death for males over females. Our results encourage evaluation of the findings among other populations.
B Xu; M R Järvelin; P Rantakallio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Social biology     Volume:  45     ISSN:  0037-766X     ISO Abbreviation:  Soc Biol     Publication Date:    1998 Fall-Winter
Date Detail:
Created Date:  1999-04-01     Completed Date:  1999-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0205621     Medline TA:  Soc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM; J    
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
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MeSH Terms
Finland / epidemiology
Infant Mortality / trends*
Infant, Newborn
Logistic Models
Maternal Age
Population Surveillance
Pregnancy Complications*
Sex Distribution
Smoking / adverse effects*

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