| Maternal smoking during pregnancy and physical control and coordination among offspring. | |
| | |
MedLine Citation:
|
PMID: 20844292 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background To examine if smoking during pregnancy is associated with poorer motor competence among offspring, indicating impaired neurological function. The measures may be less susceptible to socioeconomic confounding than cognition tests. Methods Data were from 13 207 members of the National Child Development Study, born in Great Britain in 1958. Maternal smoking during pregnancy was recorded prospectively. Tests of physical control and coordination administered by a school doctor at age 11 years were: time to pick up 20 matches (PUM), number of squares marked (NSM) and copying designs (CD). PUM and NSM were tested for left and right hand. Test scores were dependent variables in linear regression analysis, with adjustment for maternal smoking during pregnancy, sex, birth weight standardised for gestational age, breast-feeding, social class, parental education, mother's age, laterality and pubertal development. Results After adjustment, heavy smoking during pregnancy was statistically significantly associated with PUM (non-dominant hand) and CD, but not NSM; particularly among boys. The regression coefficients (and 95% CI) for PUM (non-dominant hand) are 1.474 (0.47 to 2.48, p=0.004) and 1.203 (0.15 to 2.26, p=0.026) for boys and girls, respectively: higher scores indicate poorer performance. The coefficients for CD are -0.185 (-0.32 to -0.05, p=0.006) for boys and 0.020 (-0.11 to 0.15, p=0.753) for girls: lower scores indicate poorer performance. Conclusions Smoking during pregnancy is associated with subtly reduced motor competence, particularly on the non-dominant side. Statistically significant effect modification by sex was observed for only one test, providing equivocal evidence of a sex difference. |
| | |
Authors:
|
Matz Larsson; Scott M Montgomery |
Publication Detail:
|
Type: Journal Article Date: 2010-09-15 |
Journal Detail:
|
Title: Journal of epidemiology and community health Volume: 65 ISSN: 1470-2738 ISO Abbreviation: J Epidemiol Community Health Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7909766 Medline TA: J Epidemiol Community Health Country: England |
Other Details:
|
Languages: eng Pagination: 1151-8 Citation Subset: IM |
Affiliation:
|
Department of Respiratory Medicine, Örebro University Hospital, Örebro SE-701 85, Sweden; matz.larsson@orebroll.se. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An official American Thoracic Society Workshop report: obesity and asthma.
Next Document: Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.