Document Detail

Maternal smoking during pregnancy and children's cognitive and physical development: a causal risk factor?
MedLine Citation:
PMID:  18653646     Owner:  NLM     Status:  MEDLINE    
There remains considerable debate regarding the effects of maternal smoking during pregnancy on children's growth and development. Evidence that exposure to maternal smoking during pregnancy is associated with numerous adverse outcomes is contradicted by research suggesting that these associations are spurious. The authors investigated the relation between maternal smoking during pregnancy and 14 developmental outcomes of children from birth through age 7 years, using data from the Collaborative Perinatal Project (1959-1974; n = 52,919). In addition to adjusting for potential confounders measured contemporaneously with maternal smoking, the authors fitted conditional fixed-effects models among siblings that controlled for unmeasured confounders. Results from the conditional analyses indicated a birth weight difference of -85.63 g associated with smoking of >or=20 cigarettes daily during pregnancy (95% confidence interval: -131.91, -39.34) and 2.73 times' higher odds of being overweight at age 7 years (95% confidence interval: 1.30, 5.71). However, the associations between maternal smoking and 12 other outcomes studied (including Apgar score, intelligence, academic achievement, conduct problems, and asthma) were entirely eliminated after adjustment for measured and unmeasured confounders. The authors conclude that the hypothesized effects of maternal smoking during pregnancy on these outcomes either are not present or are not distinguishable from a broader range of familial factors associated with maternal smoking.
Stephen E Gilman; Hannah Gardener; Stephen L Buka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-24
Journal Detail:
Title:  American journal of epidemiology     Volume:  168     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-31     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-31     Citation Subset:  IM    
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MeSH Terms
Behavior / drug effects
Boston / epidemiology
Child Development / drug effects
Child, Preschool
Cognition / drug effects
Cohort Studies
Confidence Intervals
Florida / epidemiology
Growth / drug effects
Infant, Newborn
Intelligence / drug effects
Mothers* / statistics & numerical data
Odds Ratio
Pregnancy Complications* / epidemiology
Prenatal Exposure Delayed Effects / epidemiology,  etiology*
Rhode Island / epidemiology
Risk Factors
Smoking / adverse effects*
Grant Support
P50 CA084719/CA/NCI NIH HHS; P50 CA084719/CA/NCI NIH HHS; P50 CA084719-10/CA/NCI NIH HHS; T32 MH017119-22/MH/NIMH NIH HHS; T32 MH17119/MH/NIMH NIH HHS
Comment In:
Obes Facts. 2014;7(2):77-81   [PMID:  24685538 ]

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