Document Detail

Maternal smoking during pregnancy and childhood lymphoma: A meta-analysis.
MedLine Citation:
PMID:  21225624     Owner:  NLM     Status:  Publisher    
Results from epidemiological studies exploring the association between childhood lymphoma and maternal smoking during pregnancy have been contradictory. This meta-analysis included all published cohort (n=2) and case-control (n=10) articles; among the latter, the data of the Greek Nationwide Registry for Childhood Hematological Malignancies (NARECHEM) study was updated to include all recently available cases (-2008). Odds Ratios (ORs), Relative Risks (RRs) and Hazard Ratios (HRs) were appropriately pooled in three separate analyses concerning Non-Hodgkin lymphoma (NHL, n=1072 cases), Hodgkin lymphoma (HL, n=538 cases) and any lymphoma (n=1591 cases), according to data availability in the included studies. An additional meta-regression analysis was conducted to explore dose-response relationships. A statistically significant association between maternal smoking (any vs. no) during pregnancy and risk for childhood NHL was observed (OR=1.22, 95% Confidence Interval, CI: 1.03-1.45, fixed effects model), whereas the risk for childhood HL was not statistically significant (OR=0.90, 95% CI: 0.66-1.21, fixed effects model). The analysis on any lymphoma did not reach statistical significance (OR=1.10, 95% CI=0.96-1.27, fixed effects model), possibly due to the case-mix of NHL to HL. No dose-response association was revealed in the meta-regression analysis. In conclusion, this meta-analysis points to a modest increase in the risk for childhood NHL, but not HL, among children born by mothers smoking during pregnancy. Further investigation of dose response phenomena in the NHL association, however, warrants accumulation of additional data.
Cn Antonopoulos; Tn Sergentanis; C Papadopoulou; E Andrie; N Dessypris; P Panagopoulou; S Polychronopoulou; A Pourtsidis; F Athanasiadou-Piperopoulou; M Kalmanti; V Sidi; M Moschovi; Et Petridou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-10
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, 11527 Athens, Greece.
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