| Maternal smoking, alcohol, and coffee use during pregnancy and son's risk of testicular cancer. | |
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MedLine Citation:
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PMID: 19303242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that increased risk for testicular cancer occurring worldwide may be due to exposures during fetal development. Lifestyle or environmental exposures may be the most important predictors of risk. However, few studies have directly examined these exposures prospectively. The Child Health and Development Studies is a 40-year follow-up of 20,530 pregnancies occurring between 1959 and 1967. There were 20 cases of testicular cancer diagnosed through 2003 among sons with a maternal interview in early pregnancy. Cases were matched to three controls on birth year and race. Odds ratios and 95% confidence intervals were calculated with exact conditional logistic regression. Compared to controls, mothers of testicular cancer cases were more likely to drink alcohol (unadjusted odds ratio, 3.2; 95% confidence interval, 0.83-15.48 for above vs. below the median for controls) and less likely to drink coffee (unadjusted odds ratio, 0.19; 95% confidence interval, 0.02-1.02 for above vs. below the median). Case mothers were neither more nor less likely to smoke. Although low power may limit interpretation of negative results, the prospective design minimizes bias. In this cohort, maternal serum testosterone in pregnancy was previously reported to be lower in women who drank alcohol. Because populations with high testicular cancer risk also have lower maternal testosterone, we suggest that testosterone could play a role in explaining the higher risk of son's testicular cancer among mothers who drank alcohol during pregnancy. |
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Authors:
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Morgana L Mongraw-Chaffin; Barbara A Cohn; Andrew T Anglemyer; Richard D Cohen; Roberta E Christianson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-03-19 |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 43 ISSN: 1873-6823 ISO Abbreviation: Alcohol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-27 Completed Date: 2009-05-28 Revised Date: 2010-02-03 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
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Languages: eng Pagination: 241-5 Citation Subset: IM |
Affiliation:
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Center for Research on Women's and Children's Health, Public Health Institute, Berkeley, CA 94709, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / adverse effects* Coffee / adverse effects* Cohort Studies Female Follow-Up Studies Humans Male Maternal Exposure / adverse effects* Neoplasms, Germ Cell and Embryonal / chemically induced Pregnancy / blood Risk Risk Factors Smoking / adverse effects* Testicular Neoplasms / chemically induced* Testosterone / blood |
| Grant Support | |
ID/Acronym/Agency:
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N01 DK63422/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coffee; 58-22-0/Testosterone |
| Comments/Corrections | |
Comment In:
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Eur Urol. 2010 Feb;57(2):357-8
[PMID:
20116771
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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