| Maternal size at birth and the development of hypertension during pregnancy: a test of the Barker hypothesis. | |
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MedLine Citation:
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PMID: 10421284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Whether individuals who were small at birth are at increased risk of developing cardiovascular disease (the Barker hypothesis) is a topic of great controversy. Although an increased risk has been suggested by several reports, the reports have been criticized for being based on ill-defined populations, for the large numbers of subjects who were unavailable for follow-up, and for inadequate control of socioeconomic status. OBJECTIVE: To determine whether a woman's weight and gestational age at birth predict the development of hypertension during her subsequent pregnancies. DESIGN: Prospective observational study. SUBJECTS: Women born in Copenhagen, Denmark, as subjects in the Danish Perinatal Study (1959-1961) were traced through the Danish Population Register. Information was obtained on their pregnancies from 1974 to 1989. MAIN OUTCOME MEASURES: Onset of hypertension in pregnancy, defined by the presence of a systolic blood pressure of 140 mm Hg or greater or a diastolic blood pressure of 90 mm Hg or greater on 2 visits at or after 140 days' gestation. RESULTS: Hypertension developed in 11.3% of the pregnant women who were small for gestational age at birth, compared with 7.2% of the pregnant women who were not small for gestational age at birth (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.1-2.6), and in 9.4% of the pregnancies in women who were preterm at birth, compared with 7.6% of pregnancies in women who were not preterm at birth (OR, 1.3; 95% CI, 0.8-2.0). After adjustment for adult body mass index, smoking, birth order, and hypertension in the subjects' own mothers, the ORs for small-for-gestational-age women and preterm women to develop hypertension during pregnancy were 1.8 (95% CI, 1.1-2.8) and 1.5 (95% CI, 0.96-2.5), respectively. CONCLUSION: These results support the Barker hypothesis, while addressing many of the methodological criticisms of previous investigations. |
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Authors:
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M A Klebanoff; N J Secher; B R Mednick; C Schulsinger |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of internal medicine Volume: 159 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-05 Completed Date: 1999-08-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1607-12 Citation Subset: AIM; IM |
Affiliation:
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Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight* Body Mass Index Confounding Factors (Epidemiology) Denmark Female Humans Hypertension / etiology*, genetics Infant, Newborn Pregnancy Pregnancy Complications, Cardiovascular / etiology* Risk Risk Factors Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-7-2902/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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