Document Detail

Maternal sickle cell anemia and neonatal isoimmunization.
MedLine Citation:
PMID:  9749883     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the risk of alloimmunization in pregnant women with sickle cell disease (SCD) and of isoimmunization in their offspring. METHOD: Thirty mothers with SCD were studied and their 35 neonates (group 1) were compared with 538 infants of mothers without hemoglobinopathies (group 2). RESULT: Six mothers with SCD developed alloantibodies. There was no correlation with maternal age (P = 0.6), parity (P = 0.18) or blood transfusions (P = 0.4). The risk of alloimmunization by transfusion was 20%. Six neonates were isoimmunized, a higher incidence than in group 2 (P = 0.02; relative risk 3.07). Five had ABO incompatibility and only one had anti-c isoimmunization. All had reticulocytosis, jaundice and required phototherapy, one developed anemia but none required blood transfusion. CONCLUSION: Although alloimmunization was common in mothers with SCD and isoimmunization in their offspring, it was rarely due to non-ABO alloantibody. There was no significant neonatal morbidity.
H Narchi; E Ekuma-Nkama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  62     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-18     Completed Date:  1998-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Specialty Services Division, Saudi-Aramco - Al-Hasa Health Center, Mubarraz, Saudi Arabia.
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MeSH Terms
Anemia, Sickle Cell / immunology*
Blood Transfusion
Infant, Newborn
Pregnancy Complications, Hematologic / immunology*
Prospective Studies
Rh Isoimmunization*

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