Document Detail

Maternal serum vascular endothelial growth factor levels in early ectopic and intrauterine pregnancies after in vitro fertilization treatment.
MedLine Citation:
PMID:  15302276     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether serum levels of vascular endothelial growth factor (VEGF) 11 days after a day-3 embryo transfer were predictive of outcome, in women with normal intrauterine pregnancy (IUP), first-trimester miscarriage (SAB), biochemical (BC), and ectopic pregnancy (EP) after IVF therapy. DESIGN: Retrospective analysis. SETTING: University hospital IVF unit. PATIENT(S): One hundred eight women who underwent IVF therapy and who were subsequently diagnosed with EP, BC, SAB, or a normal IUP (27 in each category). INTERVENTION(S): Serum samples were obtained at 11 days after a day-3 embryo transfer. MAIN OUTCOME MEASURE(S): Serum concentrations of VEGF, P, and beta-hCG. RESULT(S): Serum concentrations of VEGF were similar in women with BC and EP and higher than in women with normal IUP and SAB (571.8 +/- 61.8, 604.4 +/- 73.4 vs. 448.9 +/- 39.9, 461.8 +/- 39.2 pg/mL, respectively). Also, serum beta-hCG and P levels were significantly higher in women with a normal IUP and SAB. Using a cutoff concentration of >700 pg/mL for VEGF, an EP could be distinguished from an IUP (normal and SAB), with a positive predictive value of 64% and a negative predictive value of 71%. CONCLUSION(S): Elevated maternal serum levels of VEGF, as early as 11 days after embryo transfer, are associated with ectopic pregnancies after IVF.
Sozos J Fasouliotis; Steven D Spandorfer; Steven S Witkin; Hung-Ching Liu; Jeffrey E Roberts; Zev Rosenwaks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  82     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-10     Completed Date:  2004-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  IM    
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 305 East 70th Street, New York, NY 10021, USA.
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MeSH Terms
Abortion, Spontaneous / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Embryo Transfer
Fertilization in Vitro / adverse effects,  methods*
Oocytes / cytology
Pregnancy / blood*
Pregnancy Trimester, First
Pregnancy, Ectopic / blood*
Progesterone / blood
Retrospective Studies
Vascular Endothelial Growth Factor A / blood*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/Vascular Endothelial Growth Factor A; 57-83-0/Progesterone

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