| Maternal serum vascular endothelial growth factor levels in early ectopic and intrauterine pregnancies after in vitro fertilization treatment. | |
| | |
MedLine Citation:
|
PMID: 15302276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine whether serum levels of vascular endothelial growth factor (VEGF) 11 days after a day-3 embryo transfer were predictive of outcome, in women with normal intrauterine pregnancy (IUP), first-trimester miscarriage (SAB), biochemical (BC), and ectopic pregnancy (EP) after IVF therapy. DESIGN: Retrospective analysis. SETTING: University hospital IVF unit. PATIENT(S): One hundred eight women who underwent IVF therapy and who were subsequently diagnosed with EP, BC, SAB, or a normal IUP (27 in each category). INTERVENTION(S): Serum samples were obtained at 11 days after a day-3 embryo transfer. MAIN OUTCOME MEASURE(S): Serum concentrations of VEGF, P, and beta-hCG. RESULT(S): Serum concentrations of VEGF were similar in women with BC and EP and higher than in women with normal IUP and SAB (571.8 +/- 61.8, 604.4 +/- 73.4 vs. 448.9 +/- 39.9, 461.8 +/- 39.2 pg/mL, respectively). Also, serum beta-hCG and P levels were significantly higher in women with a normal IUP and SAB. Using a cutoff concentration of >700 pg/mL for VEGF, an EP could be distinguished from an IUP (normal and SAB), with a positive predictive value of 64% and a negative predictive value of 71%. CONCLUSION(S): Elevated maternal serum levels of VEGF, as early as 11 days after embryo transfer, are associated with ectopic pregnancies after IVF. |
| | |
Authors:
|
Sozos J Fasouliotis; Steven D Spandorfer; Steven S Witkin; Hung-Ching Liu; Jeffrey E Roberts; Zev Rosenwaks |
Related Documents
:
|
11158056 - Pregnancy-associated plasma protein-a accounts for the insulin-like growth factor (igf)... 14725946 - Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women. 5919366 - Serum uric acid levels in normal pregnancy with observations on the renal excretion of ... 3098016 - Decreased serum thyroglobulin levels in the late stage of pregnancy. 6120106 - Clinical features of pregnancies with fatal fetal abnormality. 18312796 - Urinary and anal incontinence in african american teenaged gravidas during pregnancy an... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Fertility and sterility Volume: 82 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 2004 Aug |
Date Detail:
|
Created Date: 2004-08-10 Completed Date: 2004-09-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
|
Languages: eng Pagination: 309-13 Citation Subset: IM |
Affiliation:
|
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 305 East 70th Street, New York, NY 10021, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Spontaneous
/
blood Adult Chorionic Gonadotropin, beta Subunit, Human / blood Embryo Transfer Female Fertilization in Vitro / adverse effects, methods* Humans Oocytes / cytology Pregnancy / blood* Pregnancy Trimester, First Pregnancy, Ectopic / blood* Progesterone / blood Retrospective Studies Vascular Endothelial Growth Factor A / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Chorionic Gonadotropin, beta Subunit, Human; 0/Vascular Endothelial Growth Factor A; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reproductive outcome after methotrexate treatment of tubal pregnancies.
Next Document: Incidence and characterization of diagnosed endometriosis in a geographically defined population.