Document Detail


Maternal serum superoxide dismutase (SOD): a possible marker for screening Down syndrome affected pregnancies.
MedLine Citation:
PMID:  10589060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Superoxide dismutase (SOD: EC1.15.1.1) has been shown to increase in Down syndrome (DS) subjects and in amniotic fluid from DS affected pregnancies. In order to verify a possible increase of maternal serum SOD in DS affected pregnancies and its possible contribution in prenatal screening, the serum enzyme activity was retrospectively measured in samples from normal and DS affected pregnancies. Alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated oestriol (uE3) and serum SOD were measured in serum samples collected from 80 normal and 9 DS affected second-trimester pregnancies. The maternal serum SOD activity in the DS group (3. 12+/-0.73 U/ml) was significantly higher (p<0.001) than in the control one (2.20+/-0.7 U/ml). The addition of SOD appeared to be capable of improving the sensitivity of the conventional multi-parametric test (AFP, uE3 and hCG) even if the small number of subjects did not allow the achievement of statistical significance.
Authors:
A Ognibene; R Ciuti; P Tozzi; G Messeri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  19     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1058-60     Citation Subset:  IM    
Affiliation:
Laboratory of Clinical Biochemistry, Azienda Ospedaliera Careggi, Firenze, Italy. ago@flownet.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Case-Control Studies
Chorionic Gonadotropin / blood
Down Syndrome / diagnosis*
Estriol / blood
Female
Humans
Maternal Age
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, Second
Prenatal Diagnosis / standards*
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Superoxide Dismutase / blood*
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol; EC 1.15.1.1/Superoxide Dismutase
Comments/Corrections
Comment In:
Prenat Diagn. 2000 Apr;20(4):354-5   [PMID:  10740214 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenatal diagnosis of a fetal left atrial diverticulum.
Next Document:  Severe intra-uterine growth retardation in a patient with maternal uniparental disomy 22 and a 22-tr...