Document Detail

Maternal serum superoxide dismutase (SOD): a possible marker for screening Down syndrome affected pregnancies.
MedLine Citation:
PMID:  10589060     Owner:  NLM     Status:  MEDLINE    
Superoxide dismutase (SOD: EC1.15.1.1) has been shown to increase in Down syndrome (DS) subjects and in amniotic fluid from DS affected pregnancies. In order to verify a possible increase of maternal serum SOD in DS affected pregnancies and its possible contribution in prenatal screening, the serum enzyme activity was retrospectively measured in samples from normal and DS affected pregnancies. Alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated oestriol (uE3) and serum SOD were measured in serum samples collected from 80 normal and 9 DS affected second-trimester pregnancies. The maternal serum SOD activity in the DS group (3. 12+/-0.73 U/ml) was significantly higher (p<0.001) than in the control one (2.20+/-0.7 U/ml). The addition of SOD appeared to be capable of improving the sensitivity of the conventional multi-parametric test (AFP, uE3 and hCG) even if the small number of subjects did not allow the achievement of statistical significance.
A Ognibene; R Ciuti; P Tozzi; G Messeri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  19     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1058-60     Citation Subset:  IM    
Laboratory of Clinical Biochemistry, Azienda Ospedaliera Careggi, Firenze, Italy.
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Chorionic Gonadotropin / blood
Down Syndrome / diagnosis*
Estriol / blood
Maternal Age
Predictive Value of Tests
Pregnancy Trimester, Second
Prenatal Diagnosis / standards*
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Superoxide Dismutase / blood*
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol; EC Dismutase
Comment In:
Prenat Diagn. 2000 Apr;20(4):354-5   [PMID:  10740214 ]

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